Growth factors in pulmonary arterial hypertension: Focus on preserving right ventricular function

Physiology International
G CsószaZ Lázár

Abstract

Pulmonary arterial hypertension (PAH) is a rare and progressive disease, characterized by increased vascular resistance leading to right ventricle (RV) failure. The extent of right ventricular dysfunction crucially influences disease prognosis; however, currently no therapies have specific cardioprotective effects. Besides discussing the pathophysiology of right ventricular adaptation in PAH, this review focuses on the roles of growth factors (GFs) in disease pathomechanism. We also summarize the involvement of GFs in the preservation of cardiomyocyte function, to evaluate their potential as cardioprotective biomarkers and novel therapeutic targets in PAH.

References

Jul 6, 1990·Science·A M LeferM A Palladino
Feb 23, 1995·Molecular and Cellular Biochemistry·R R PaduaE Kardami
May 1, 1995·Circulation Research·A P LevyM A Goldberg
Sep 1, 1996·Molecular and Cellular Biology·J A ForsytheG L Semenza
Nov 14, 1997·The Annals of Thoracic Surgery·Z LuoJ F Symes
Feb 28, 1998·Journal of Molecular and Cellular Cardiology·M A HeftiM C Schaub
Oct 6, 1998·Annual Review of Biochemistry·D A FrumanL C Cantley
May 27, 1999·Seminars in Cancer Biology·T Veikkola, K Alitalo
Sep 24, 1999·The Journal of Clinical Investigation·J E SchultzT Doetschman
Dec 6, 2000·American Journal of Respiratory Cell and Molecular Biology·C PartovianS Eddahibi
Feb 7, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·L Taraseviciene-StewartR M Tuder
Feb 17, 2001·American Journal of Physiology. Heart and Circulatory Physiology·F SheikhP A Cattini
Feb 9, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Zhi-Sheng JiangElissavet Kardami
Jan 28, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Vanessa LouzierSerge Adnot
Apr 15, 2003·The Journal of Gene Medicine·Wei ChaoAnthony Rosenzweig
Sep 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Julie R McMullenSeigo Izumo
Mar 10, 2004·The Journal of Experimental Medicine·Munira XaymardanJay M Edelberg
Sep 14, 2004·American Journal of Respiratory and Critical Care Medicine·Amy RichterRubin M Tuder
Jan 18, 2005·Coronary Artery Disease·Kelly M ChinLewis J Rubin
Aug 10, 2005·Journal of Cellular Biochemistry·Shuan S Huang, Jung S Huang
Oct 4, 2005·The Journal of Clinical Investigation·Ralph Theo SchermulyFriedrich Grimminger
Oct 27, 2006·Proceedings of the American Thoracic Society·Nicholas W Morrell
Dec 13, 2006·Journal of the American College of Cardiology·Pawel ZymekNikolaos G Frangogiannis
Feb 1, 2007·Molecular and Cellular Biochemistry·YeQing PiJosé Marín-García
May 23, 2007·Heart Failure Reviews·Elissavet KardamiPeter A Cattini
Oct 31, 2007·Circulation·Marcin BujakNikolaos G Frangogiannis
Jan 19, 2008·American Journal of Respiratory and Critical Care Medicine·Ari L ZaimanRubin M Tuder
Apr 19, 2008·American Journal of Respiratory and Critical Care Medicine·Frédéric PerrosMarc Humbert
Feb 17, 2009·Cardiovascular Research·Derek J Hausenloy, Derek M Yellon
Mar 28, 2009·The European Respiratory Journal·N SelimovicB Rundqvist
Jul 9, 2009·Journal of the American College of Cardiology·Rajiv D MachadoWendy K Chung
Mar 24, 2010·Journal of Molecular and Cellular Cardiology·Marius VantlerWolfram-H Zimmermann
May 18, 2010·Journal of the American Society of Hypertension : JASH·Jesus L AlmendralSteven A Atlas

❮ Previous
Next ❯

Citations

May 7, 2021·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Aya YamamuraMotohiko Sato

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the American College of Cardiology
Anton Vonk-NoordegraafPaul M Hassoun
American Journal of Respiratory and Critical Care Medicine
Marius M Hoeper, John Granton
International Journal of Clinical Practice. Supplement
Anna R Hemnes, H C Champion
Türk Kardiyoloji Derneği arşivi : Türk Kardiyoloji Derneğinin yayın organıdır
Anton Vonk-NoordegraafPaul M Hassoun
Annals of the American Thoracic Society
Jose Gomez-ArroyoHarm J Bogaard
© 2021 Meta ULC. All rights reserved