Growth factors: possible roles for clinical management of the short bowel syndrome.

Seminars in Pediatric Surgery
Mark E McMellenB W Warner

Abstract

The structural and functional changes during intestinal adaptation are necessary to compensate for the sudden loss of digestive and absorptive capacity after massive intestinal resection. When the adaptive response is inadequate, short bowel syndrome (SBS) ensues and patients are left with the requirement for parenteral nutrition and its associated morbidities. Several hormones have been studied as potential enhancers of the adaptation process. The effects of growth hormone, insulin-like growth factor-1, epidermal growth factor, and glucagon-like peptide 2 on adaptation have been studied extensively in animal models. In addition, growth hormone and glucagon-like peptide 2 have shown promise for the treatment of SBS in clinical trials in human beings. Several lesser studied hormones, including leptin, corticosteroids, thyroxine, testosterone, and estradiol, are also discussed.

References

Oct 11, 1991·International Journal of Dermatology·R A YatesL E King
Nov 1, 1989·Journal of Reproduction and Fertility·B W BrownG H Brown
Aug 1, 1994·Journal of Pediatric Surgery·M S ChaetB W Warner
Jun 1, 1994·The Journal of Clinical Endocrinology and Metabolism·M C Delehaye-ZervasM C Postel-Vinay
Jul 1, 1995·JPEN. Journal of Parenteral and Enteral Nutrition·T A ByrneD W Wilmore
Jul 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·D J DruckerP L Brubaker
Oct 1, 1998·Scandinavian Journal of Gastroenterology·M WøjdemannJ J Holst
Nov 14, 1998·The American Journal of Physiology·R B ScottJ B Meddings
Feb 3, 1999·Annals of the New York Academy of Sciences·P K Lund
Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·D G MunroeA Crivici
Mar 19, 1999·Protein Science : a Publication of the Protein Society·K J BarnhamR S Norton
Oct 3, 1999·Journal of Pediatric Surgery·B VelascoJ A Tovar
Oct 26, 1999·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·J C de AgustinE Alvarez
Oct 31, 2000·Microscopy Research and Technique·L E SternB W Warner
Sep 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·M Bjerknes, H Cheng
Mar 5, 2003·Pharmacological Reviews·Kelly E MayoDaniel J Drucker
Dec 4, 2003·Best Practice & Research. Clinical Gastroenterology·J SchalamonM E Höllwarth
Feb 14, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Gary R MartinDavid L Sigalet
Mar 16, 2004·Journal of Pediatric Surgery·Anita M NucciEdward M Barksdale
Dec 1, 2004·JPEN. Journal of Parenteral and Enteral Nutrition·Zhu WeimingLi Jieshou
Feb 18, 2005·JPEN. Journal of Parenteral and Enteral Nutrition·James M KielyDeborah A Swartz-Basile
Mar 29, 2005·Journal of Pediatric Surgery·Igor SukhotnikMichael M Krausz
Dec 6, 2005·Pediatric Surgery International·Igor SukhotnikJorge G Mogilner

❮ Previous
Next ❯

Citations

Jan 14, 2012·Current Opinion in Gastroenterology·Sarah F Bortvedt, P Kay Lund
Mar 17, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Meredith C HitchBrad W Warner
Mar 29, 2012·Paediatric Drugs·Victor UkoNaim Alkhouri
Dec 1, 2012·World Journal of Gastroenterology : WJG·Darcy ShawMarc D Basson
Mar 8, 2013·Journal of Tissue Engineering and Regenerative Medicine·Yasuhiro TorashimaTracy C Grikscheit
Apr 25, 2013·Seminars in Pediatric Surgery·Kathryn J RowlandBrad W Warner
Mar 14, 2013·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Huafang YuXiaoming Fan
Jan 22, 2013·Journal of Pediatric Surgery·Brad W Warner
Nov 20, 2012·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·O GouletR M Beattie
Oct 27, 2012·Endocrinology and Metabolism Clinics of North America·Alba Morales Pozzo, Stephen F Kemp
Jul 1, 2012·Obesity Research & Clinical Practice·Noriko IshizukaShuji Inoue
Feb 15, 2011·Expert Opinion on Therapeutic Targets·Pamela J Hornby, Beverley A Moore
Oct 11, 2016·Cellular and Molecular Gastroenterology and Hepatology·Brad W Warner
Feb 6, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Maria Grazia AmmendoliaBarbara De Berardis
Mar 4, 2014·JPEN. Journal of Parenteral and Enteral Nutrition·Kelly A Tappenden
Jun 1, 2018·Expert Opinion on Drug Safety·Bharati Kochar, Hans H Herfarth
Apr 4, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Laurianne Van LandeghemP Kay Lund
May 10, 2018·The Journal of Clinical Endocrinology and Metabolism·Adile OrhanHannelouise Kissow
Jun 20, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·K A SchallT C Grikscheit
Jul 25, 2019·Pediatric Gastroenterology, Hepatology & Nutrition·Olivier GouletCécile Lambe
Feb 15, 2017·Drugs·Esther S Kim, Susan J Keam
Jan 5, 2021·Pediatric Surgery International·Michael E Höllwarth, Valeria Solari
Sep 9, 2020·Cellular and Molecular Gastroenterology and Hepatology·Yoko YagishitaNobunao Wakabayashi
Dec 15, 2020·Current Treatment Options in Pediatrics·Baddr A Shakhsheer, Brad W Warner
Apr 30, 2021·Expert Review of Proteomics·Noemi ZorzettiAugusto Lauro
Jun 27, 2021·International Journal of Biological Macromolecules·Omid Jamshidi KandjaniSiavoush Dastmalchi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.