Growth Factors Release From Concentrated Growth Factors: Effect of β-Tricalcium Phosphate Addition

The Journal of Craniofacial Surgery
Veronica BonazzaLuigi Fabrizio Rodella

Abstract

Platelet concentrates represent a new approach to improve tissue regeneration and can be used alone or together with autogenous bone, recombinant human growth factors, and/or other biomaterials, to enhance tissue regeneration. Among platelet concentrates, concentrated growth factors (CGFs) exhibit an interesting clinical and biotechnological application potential. The aim of this study was to evaluate the in vitro release of 4 growth factors (bone morphogenetic proteins [BMP] -2, BMP-7, transforming growth factor [TGF] -β1, and insulin-like growth factor [IGF] -1) by the enzyme-linked immunosorbent assay (ELISA) technique, in CGFs mixed or not with β-tricalcium phosphate (β-TCP), using or not the Round-up device, at different times. CGFs were obtained from healthy volunteers, mixed or not with β-TCP, using or not the Round-up device. The release of 4 growth factors from these CGFs was then measured at 5 hours, 1, 3, 6, and 8 days, using the ELISA assay. Comparison of the results obtained with those achieved for CGFs alone showed that BMP2 and BMP-7 release, significantly increased in CGFs mixed with Round-up and β-TCP, TGF-β1 release was similar to CGFs alone, whereas IG-1 release was lower compared with CGFs alone. The present...Continue Reading

References

Oct 17, 1998·Journal of Periodontology·V LekovicM Nedic
Jan 5, 2002·Journal of Biomedical Materials Research·J ZieglerK-P Günther
Sep 5, 2002·Journal of Biomedical Materials Research·Akira OgoseHajime Umezu
Sep 11, 2003·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Rumi FujitaTakao Kohgo
Dec 24, 2003·Thrombosis and Haemostasis·Eduardo AnituaAlan T Nurden
Nov 19, 2005·Expert Review of Medical Devices·Ahmed El-Ghannam
Jun 3, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·M P GinebraJ A Planell
Jan 18, 2007·Journal of Cellular Physiology·Tingjiao LiuAkira Yamaguchi
Aug 25, 2007·Nanomedicine·Tanya TraykovaJosep A Planell
Jan 28, 2009·Transfusion·Georges BettegaMarie Jeanne Richard
May 9, 2009·Journal of Thrombosis and Haemostasis : JTH·D Varga-SzaboB Nieswandt
Jul 8, 2009·Bio-medical Materials and Engineering·Junichi TazakiYasuhiko Tabata
Sep 28, 2010·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Pascal JungbluthMohssen Hakimi
Jan 1, 2010·The Open Biomedical Engineering Journal·P WongwitwichotB H I Ruszymah
Jun 2, 2011·BMC Medicine·Rozalia DimitriouPeter V Giannoudis
Jul 23, 2011·Microscopy Research and Technique·Luigi Fabrizio RodellaRita Rezzani
Mar 2, 2012·Journal of Maxillofacial and Oral Surgery·Shobha Prakash, Aditi Thakur
Jul 16, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Sema S HakkiErdal Karaoz
Nov 12, 2013·Sports Medicine and Arthroscopy Review·Geoffrey D AbramsBrian J Cole
Nov 20, 2013·Experimental and Therapeutic Medicine·César RiveraIván Suazo
Dec 20, 2013·Tissue Engineering. Part a·Darilis Suárez-GonzálezWilliam L Murphy
Jun 4, 2014·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Farhang AlaeeJay R Lieberman
Feb 13, 2015·The Journal of Craniofacial Surgery·Jingwen YangYunzhi Yang
Mar 25, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Tao WangDaniel D Bikle
Jun 5, 2015·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Siniga MirkovićTatjana Pugkar
Sep 24, 2015·The International Journal of Oral & Maxillofacial Implants·Yukihiro TakedaTakashi Inoue
Dec 19, 2015·Cytokine & Growth Factor Reviews·Katharina Schmidt-BleekGeorg N Duda
Jul 19, 2016·The Journal of Craniofacial Surgery·Mustafa Cenk DurmuşlarSevil Altindağ Kahraman
Sep 19, 2016·Microscopy Research and Technique·Veronica BonazzaLuigi Fabrizio Rodella

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Feb 25, 2020·Journal of Biomedical Materials Research. Part a·Fahimeh TabatabaeiLobat Tayebi

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