PMID: 9180116Jun 1, 1997Paper

Growth factors released into the coronary circulation after vascular injury promote proliferation of human vascular smooth muscle cells in culture

Journal of the American College of Cardiology
N M CapliceM J West

Abstract

This study sought to 1) assess in vivo release of platelet-derived growth factor (PDGF) and basic fibroblast growth factor (bFGF) into the coronary circulation after vascular injury in human subjects; and 2) evaluate mitogenic effects of PDGF and bFGF on the patient's own vascular smooth muscle cells (VSMCs). Circumstantial evidence suggests involvement of PDGF and bFGF peptides in the neointimal response to vascular injury. To date, no study has shown biologically active growth factors within the coronary circulation after vascular injury in human subjects. In 18 patients, plasma PDGF AB, platelet factor 4 (PF4) and beta-thromboglobulin (beta-TG) levels were measured in coronary sinus blood obtained before and up to 30 min after angioplasty. In five patients undergoing atherectomy, coronary sinus serum was added to cultured VSMCs derived from atherectomy tissue to assess the mitogenic potential of the serum. Mitogenicity attributable to PDGF and bFGF was determined using neutralizing antibodies to these factors. PDGF A, PDGF B and bFGF were localized within the atherectomy tissue using immunocytochemical analysis. Before angioplasty, PDGF AB, PF4 and beta-TG levels were elevated threefold in patients scheduled for angioplasty ...Continue Reading

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Citations

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Jun 26, 2001·British Journal of Clinical Pharmacology·J GraffS Harder
Jun 8, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·G CiancioloV Stefoni
Jul 24, 2010·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Xiao Yi FangYu Guang Li
Jun 22, 2013·Proteomics. Clinical Applications·Zongming FuJennifer Van Eyk
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Jun 18, 2004·Coronary Artery Disease·Jingang ZhengJay M Edelberg
Aug 27, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Grace J WangMichael S Conte
Jun 29, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Anne Marie ThompsonEva M Rzucidlo
Jul 15, 2000·Coronary Artery Disease·S KorovesisD Katritsis
Oct 21, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·G CiancioloG La Hanna
Mar 4, 2000·American Journal of Hypertension·S CottoneG Cerasola
Jan 10, 2003·The International Journal of Artificial Organs·G DonatiS Stefoni

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