PMID: 11906643Mar 22, 2002Paper

Growth following solid-organ transplantation

Pediatric Transplantation
Richard N Fine

Abstract

One of the ultimate goals of successful transplantation (Tx) in pediatric solid-organ transplant recipients is the attainment of optimal final adult height. Except for kidney Tx there are limited data to address this issue. Remarkably similar factors impact on growth in pediatric kidney, liver, and heart recipients. Age is a primary factor, with younger recipients exhibiting the greatest immediate catch-up growth. Graft function is a significant contributory factor: a reduction in glomerular filtration rate (GFR) correlates with poor growth in kidney recipients, and the need for re-Tx is associated with impaired growth in liver recipients. The known adverse impact of corticosteroids on growth has led transplant physicians/surgeons to either modify the dose or attempt steroid withdrawal. In kidney and liver recipients this is associated with the development of acute rejection episodes. In infant heart transplant recipients the avoidance of maintenance corticosteroid immunosuppression is associated with normal growth velocity in the majority of recipients. With the marked improvement in patient and graft survival rates in pediatric solid-organ graft recipients, it is timely that the quality-of-life issues receive paramount attent...Continue Reading

References

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Citations

Jun 14, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Adi CohenElizabeth Shane
Sep 18, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Roger W EvansJoren C Madsen
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Mar 31, 2004·Pediatric Transplantation·Adi CohenElizabeth Shane
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Aug 17, 2006·Pediatric Transplantation·Marian PorubskyEnrico Benedetti
Jan 24, 2004·Pediatric Transplantation·P D AcottJ A Wong
Mar 4, 2011·Pediatric Transplantation·Louise Aarup BrodersenPeter Marckmann
Nov 7, 2019·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Alicia M AlcamoRajesh K Aneja
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May 10, 2008·Pediatric Transplantation·Renuka E PetersonRuey-Kang R Chang
Jul 22, 2004·Pediatric Transplantation·Jeffrey M Saland
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Sep 28, 2007·The New England Journal of Medicine·Timothy W Meyer, Thomas H Hostetter
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Nov 9, 2011·Journal of Pediatric Gastroenterology and Nutrition·Ekkehard Sturm
Mar 31, 2004·Pediatric Transplantation·Eba H Hathout, Richard E Chinnock
Mar 11, 2004·Pediatric Transplantation·Richard N FineRobert E Gore-Langton
Dec 16, 2004·Pediatric Transplantation·Raymond RedingRichard Fine
Mar 9, 2011·Pediatrics·Christopher LaRosaKevin E C Meyers

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