Growth fractions of human renal cell carcinoma defined by monoclonal antibody Ki-67. Predictive values for prognosis

International Journal of Urology : Official Journal of the Japanese Urological Association
H YubaS Ohshima

Abstract

We used immunohistochemical techniques to elucidate the role of growth fractions of renal cell carcinoma in the clinicopathology of the condition and patient survival. Fifty-two fresh-frozen nephrectomy specimens were immunostained with Ki-67 monoclonal antibody. Ki-67 indexes were determined to examine the relationship between tumor size, grade, stage and survival curve. This study included 43 men and nine women with the mean age 58.4 +/- 11.7 years, who had been followed up for 39 +/- 25 months. The Ki-67 index ranged from 0.6 to 14.1%, averaging 4.6 +/- 5.8%. It was 2.8 +/- 2.4% in tumors <5 cm, 4.7 +/- 3.6% in tumors > or =5 cm and 7.1 +/- 9.0% in tumors > or =10 cm. The Ki-67 index of grades 1, 2 and 3 tumors was 2.3 +/- 1.1%, 3.3 +/- 2.7% and 12.0 +/- 10.4%, respectively. Grade 3 tumors had a significantly higher Ki-67 index than grade 1 or grade 2 tumors. There was no correlation between the Ki-67 index and tumor stage. Patients with a Ki-67 index < 5.6% had a better prognosis than those with an index > 5.6% (P=0.029). However, multivariate analysis demonstrated that tumor size (P=0.034) and grade (P=0.038) were higher in hazard ratio than the Ki-67 index. Most renal cell carcinomas had low growth fractions. Although a h...Continue Reading

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Citations

Jan 22, 2003·International Journal of Urology : Official Journal of the Japanese Urological Association·Toshiro OdaTaiji Tsukamoto
Apr 29, 2008·Cancer Treatment Reviews·D FurnissUNKNOWN National Cancer Research Institute Renal Clinical Studies Group
Nov 29, 2015·The Urologic Clinics of North America·Laura-Maria KrabbeYair Lotan
Apr 12, 2005·The Journal of Urology·Hyung L KimRobert A Figlin

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