PMID: 7538403May 1, 1995Paper

Growth hormone administration in addition to a very low calorie diet and an exercise program in obese subjects

European Journal of Endocrinology
M L DrentE A van der Veen

Abstract

A major problem of weight reduction in obesity is the undesirable loss of lean body mass that accompanies fat loss, particularly in severe calorie restriction. In order to achieve maximal fat loss, but without great loss of lean tissue, growth hormone (GH) in a dose of 6 U/day subcutaneously was added to a very low calorie diet and an exercise program for moderately obese subjects. Body weight, body composition and hormonal status were studied during an eight-week period. The results of seven patients using GH (seven females; mean age 39.1 +/- 7.9 years; mean body weight 94.2 +/- 10.7 kg; mean body mass index 35.1 +/- 2.3 kg/m2) were compared to the results of eight patients using placebo (two males, six females; mean age 38.9 +/- 10.4 years; 100.0 +/- 11.0 kg; mean body mass index 32.9 +/- 1.9 kg/m2). The groups were comparable for demographic data. Both serum insulin-like growth factor I (IGF-I) and IGF binding protein 3 (IGFBP-3) levels became significantly higher in the GH group (p = 0.001 and p = 0.014, respectively). Mean serum IGF-I levels increased from 29.0 +/- 8.19 nmol/l at randomization to 50.14 +/- 14.66 nmol/l after 2 weeks in the GH group, whereas the levels decreased from 34.25 +/- 10.26 nmol/l to 27.63 +/- 8.14...Continue Reading

Citations

Apr 10, 2013·Nature Reviews. Endocrinology·Darlene E BerrymanGudmundur Johannsson
Mar 29, 2008·Metabolic Syndrome and Related Disorders·Thue Johansen, Kjell Malmlöf
Sep 27, 2012·American Journal of Physiology. Endocrinology and Metabolism·Andrea S CornfordJeffrey F Horowitz
Apr 4, 2000·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·P VestergaardB Richelsen
May 18, 2005·Sports Medicine·Robert G McMurray, Anthony C Hackney
Sep 3, 2009·Molecular and Cellular Endocrinology·Michael Højby Rasmussen
Mar 21, 2007·Clinical Endocrinology·Amar Agha, John P Monson
Feb 11, 2005·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·T JohansenK Malmlöf
Nov 25, 2004·Best Practice & Research. Clinical Gastroenterology·L Van GaalH J Verkade
Feb 13, 2003·Obesity Research·Samyah Shadid, Michael D Jensen
Jul 31, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·S Y NamK B Huh
Dec 22, 1999·Endocrine Reviews·G A Bray, F L Greenway
May 3, 2003·The Journal of Clinical Endocrinology and Metabolism·Jeremy W TomlinsonPaul M Stewart
Jan 1, 2008·Expert Review of Endocrinology & Metabolism·Martine RixhonAlbert Beckers
Oct 23, 2008·The Journal of Clinical Endocrinology and Metabolism·Kavya C Mekala, Nicholas A Tritos
Apr 22, 2006·Arquivos brasileiros de endocrinologia e metabologia·Alfredo HalpernAna Paula A C Costa
Dec 1, 1996·Endocrinology and Metabolism Clinics of North America·S R Smith

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