Growth hormone and heart failure: oxidative stress and energetic metabolism in rats

Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society
Fábio Rodrigues Ferreira SeivaE L B Novelli

Abstract

Several evidences point for beneficial effects of growth hormone (GH) in heart failure (HF). Taking into account that HF is related with changes in myocardial oxidative stress and in energy generation from metabolic pathways, it is important to clarify whether GH increase or decrease myocardial oxidative stress and what is its effect on energetic metabolism in HF condition. Thus, this study investigated the effects of two different doses of GH on energetic metabolism and oxidative stress in myocardium of rats with HF. Male Wistar rats (n=25) were submitted to aortic stenosis (AS). The HF was evidenced by tachypnea and echocardiographic criteria around 28 weeks of AS. The rats were then randomly divided into three groups: (HF) with HF, treated with saline (0.9% NaCl); (HF-GH1), treated with 1 mk/kg/day recombinant human growth hormone (rhGH), and (HF-GH2) treated with 2 mg/kg/day rhGH. GH was injected, subcutaneously, daily for 2 weeks. A control group (sham; n=12), with the same age of the others rats was evaluated to confirm data for AS. HF had lower IGF-I (insulin-like growth factor-I) than sham-operated rats, and both GH treatments normalized IGF-I level. HF-GH1 animals had lower lipid hydroperoxide (LH), LH/total antioxidan...Continue Reading

References

Jul 1, 1974·Annals of Internal Medicine·W L McGuffinP L Frommer
Sep 1, 1969·European Journal of Biochemistry·A BassD Pette
Jun 1, 1995·European Journal of Endocrinology·R J Ross, S L Chew
Dec 10, 1995·Analytical Biochemistry·J F Ewing, D R Janero
Aug 1, 1996·Medical Hypotheses·D Romero-AlviraL Placer
Jun 1, 1997·European Journal of Clinical Investigation·J IsgaardB A Bengtsson
May 15, 1998·Journal of the American College of Cardiology·M KeithK N Jeejeebhoy
Dec 19, 1998·European Heart Journal·J IsgaardB A Bengtsson
Sep 1, 1999·Clinical Endocrinology·F BroglioE Ghigo
Oct 16, 1999·The New England Journal of Medicine·M L Vance, N Mauras
Feb 2, 2000·Proceedings of the Society for Experimental Biology and Medicine·R T Mallet
Sep 21, 2000·The American Journal of Medicine·D J Lefer, D N Granger
Feb 24, 2001·Clinical Endocrinology·A ColaoG Lombardi
Aug 14, 2001·American Journal of Physiology. Endocrinology and Metabolism·K OkamotoD O Jacobs
Jul 11, 2002·Journal of the American College of Cardiology·Víctor G Dávila-RománRobert J Gropler
Feb 1, 2003·International Journal of Cardiology·Panagiotis E KontoleonJohn N Nanas
Mar 26, 2003·Coronary Artery Disease·Philip A MacCarthy, Ajay M Shah
Jun 6, 2003·Endocrine Reviews·R N Clayton
Jun 20, 2003·Journal of Cardiac Failure·Mariantonietta CicoiraStefan D Anker
Jun 25, 2003·Journal of the American College of Cardiology·Antonio CittadiniLuigi Saccà
Nov 25, 2003·International Journal of Experimental Pathology·Robson Francisco CarvalhoMaeli Dal Pai-Silva
Jan 14, 2004·Canadian Journal of Physiology and Pharmacology·Yeda S DinizEthel L B Novelli
Mar 15, 2005·The Journal of Clinical Investigation·Frank J Giordano
Jun 30, 2005·Experimental Biology and Medicine·Robert T MalletAlbert H Olivencia-Yurvati
Jul 1, 2005·Physiological Reviews·William C StanleyGary D Lopaschuk
Sep 1, 2005·Journal of Biomedical Science·Mario Mateus SugizakiAntonio Carlos Cicogna
Feb 14, 2006·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M F PinottiA C Cicogna
Jul 1, 2006·Arquivos brasileiros de cardiologia·Vanessa Oliveira MoreiraKatashi Okoshi
Jul 15, 2006·International Journal of Cardiology·Edson A BregagnolloAntonio C Cicogna
Aug 19, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kevin C Kregel, Hannah J Zhang

❮ Previous
Next ❯

Citations

Mar 27, 2013·Naunyn-Schmiedeberg's Archives of Pharmacology·Caixia LiPin-Lan Li
Jun 22, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Cai-Xia LiPin-Lan Li
May 22, 2010·Expert Opinion on Pharmacotherapy·Megha AgarwalErnst R Schwarz
Dec 9, 2008·Journal of Molecular and Cellular Cardiology·Smita SihagJohn J Lehman
Jan 20, 2011·Clinical Science·Elena ContiMassimo Volpe
Dec 23, 2014·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·James KeaneBon Gray
Feb 24, 2011·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L G A ChuffaF E Martinez
Jan 7, 2010·Journal of Cardiovascular Pharmacology·Olfat Shaker, Doaa A Sourour
Jan 19, 2017·Oncotarget·Mariana Janini GomesMarina Politi Okoshi
Jan 5, 2017·Oxidative Medicine and Cellular Longevity·Pere BarcelóRubén V Rial

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Related Papers

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Nicholas A Tritos, Peter G Danias
International Journal of Cardiology
Y S DinizE L B Novelli
Neurochemistry International
Stephen C Bondy, Edward H Sharman
© 2021 Meta ULC. All rights reserved