Growth hormone and mild exercise in combination markedly enhance cortical bone formation and strength in old rats

Endocrinology
H OxlundT T Andreassen

Abstract

The effects of a combination of mild exercise and GH injections on bone were studied in old female rats. Biosynthetic human GH, 2.7 mg/kg/day, was injected s.c. for 73 days. Exercised rats ran 8 m/min on a treadmill for 1 h/day. All rats (age 21 months old) were labeled with a tetracycline injection 56 days and a calcein injection 11 days before killing. The GH injections resulted in an 11-fold increase in femoral middiaphyseal bone formation rate and a 12% increase in cross-sectional area compared with the saline-injected group. The mild exercise doubled the mineralizing surface but did not influence the bone formation rate significantly. The combination of GH injections plus exercise, however, resulted in a further increase of 39% in bone formation rate, primarily at the anterolateral aspects, and an increase of 5% in cross-sectional area compared with the group injected with GH only. The femur ultimate breaking load was increased by 37% and the stiffness by 42% in the group injected with GH compared with the saline-injected group. Exercise alone did not influence the femur mechanical properties. The combination of GH injections plus exercise induced a 4% further increase in ultimate breaking load and 7% further increase in s...Continue Reading

References

Apr 1, 1992·Calcified Tissue International·C T RubinK J McLeod
Jan 1, 1991·Hormone Research·D RudmanM W Draper
Mar 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K M NewhallR Marcus
Jan 1, 1989·The Journal of Clinical Investigation·E CanalisT L McCarthy
Aug 1, 1987·Neuroendocrinology·S TakahashiJ Meites
Sep 1, 1987·The Anatomical Record·H M Frost
Jul 1, 1985·Calcified Tissue International·C T Rubin, L E Lanyon
Jan 1, 1972·Calcified Tissue Research·W H HarrisE H Weinberg
Jul 1, 1968·Biochemical Pharmacology·J AerO Laitinen
Oct 1, 1984·The Journal of Clinical Endocrinology and Metabolism·A E BennettR L Hintz
Jan 1, 1980·Journal of Biomedical Engineering·J Perkins
May 1, 1981·The Journal of Clinical Investigation·D RudmanR P Bain
Jan 1, 1981·Journal of Perinatal Medicine·R Terinde
Jul 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T T AndreassenH Oxlund
Sep 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M KassemE F Eriksen
Feb 1, 1994·European Journal of Endocrinology·C EjerstedH Oxlund
Jun 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J PfeilschifterR Ziegler
Dec 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K BrixenL Mosekilde
Oct 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C H TurnerI Owan
Aug 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T T AndreassenH Oxlund

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Citations

Mar 14, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S SehmischE K Stuermer
Sep 2, 2008·Journal of Bone and Mineral Metabolism·Jameela BanuGabriel Fernandes
Mar 25, 2006·Lipids in Health and Disease·Jameela BanuGabriel Fernandes
Nov 25, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T T Andreassen, H Oxlund
Jan 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M R ForwoodM B Bennett
Nov 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Klara SjögrenClaes Ohlsson
Mar 16, 2001·Experimental Gerontology·A Viidik
Mar 15, 2006·Dental Clinics of North America·Derrick C WanMichael T Longaker
Dec 16, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Joel D BoerckelRobert E Guldberg
Dec 12, 2001·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·N B AndersenH Oxlund
Feb 1, 2007·Journal of Cellular Biochemistry·Takahiro KannoTatsuji Nishihara
Feb 24, 2005·Experimental Animals·Jun IwamotoYoshihiro Sato
Aug 21, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Gisela Rodrigues da Silva SassoManuel de Jesus Simões
Jan 26, 2013·Climacteric : the Journal of the International Menopause Society·R Florencio-SilvaR D Reginato
Aug 28, 2020·Frontiers in Nutrition·Diana Zukas AndreottiElisa Mitiko Kawamoto
Sep 27, 2020·Life·Hugues PortierStéphane Pallu
Dec 13, 2016·Acta Biomaterialia·Laxminarayanan KrishnanRobert E Guldberg

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