PMID: 9437576Jan 23, 1998Paper

Growth hormone and Pit-1 expression in bovine fetal lymphoid cells

Domestic Animal Endocrinology
H T ChenR D Schultz

Abstract

Bovine fetal lymphoid cells were examined for growth hormone (GH) and the transcription factor Pit-1/GHF-1 mRNA. GH and Pit-1/GHF-1 transcripts were detected in thymocytes and splenocytes from fetuses at 60, 90, 120, and 270 d of gestation using reverse transcription-polymerase chain reaction (RT-PCR). Northern analysis indicated that the lymphoid GH mRNA was approximately 350 nucleotides larger than in the pituitary. RT-PCR analysis demonstrated that the coding regions as well as 3' untranslated region of the lymphocyte GH and pituitary transcripts were the same. Analysis of the 5'-untranslated region of the lymphocyte GH mRNA showed that transcription began upstream from the start site in the pituitary gland, suggesting differences in regulation in these tissues. Fetal thymocytes and splenocytes expressed Pit-1/GHF-1 mRNA; however, they contained only the 2.5-kb transcript. The GH and Pit-1/GHF-1 mRNA in fetal lymphoid cells supports the hypothesis that lymphocyte-derived GH may function as an autocrine and/or paracrine factor during the development and maturation of the bovine fetal immune system.

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Citations

Jul 8, 2005·Cell and Tissue Research·Yasuhiro NagaiTakahiro Yamaguchi
Oct 26, 2010·Endocrine·S Harvey
Nov 2, 2013·Cellular Immunology·Douglas A Weigent
Jul 20, 1999·Molecular and Cellular Endocrinology·I S Lantinga-van LeeuwenJ A Mol
Jan 23, 1998·Domestic Animal Endocrinology·H T ChenR D Schultz
Jan 16, 2009·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Naoki Hattori
Sep 30, 2014·Acta Microbiologica Et Immunologica Hungarica·György Csaba
Jan 10, 2001·Canadian Journal of Physiology and Pharmacology·S HarveyK L Hull
May 4, 1999·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·S Chappel
Jan 28, 2003·Molecular Reproduction and Development·E M JoudreyW A King

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