PMID: 3763594Nov 1, 1986Paper

Growth hormone and prolactin secretion after hypothalamic deafferentation in pigs

Proceedings of the Society for Experimental Biology and Medicine
J R MolinaLloyd L Anderson

Abstract

Control of growth hormone (GH) and prolactin (PRL) secretion was investigated in ovariectomized, prepuberal Yorkshire gilts by comparing the effects of anterior (AHD), complete (CHD), and posterior (PHD) hypothalamic deafferentation with sham-operated controls (SOC). Blood samples were collected sequentially via an indwelling jugular catheter at 20-min intervals during surgery and recovery from anesthesia (Day 0) and Days 1 and 2 after cranial surgery. Mean serum concentrations of GH after AHD, CHD, and PHD were reduced (P less than 0.01) when compared with SOC gilts. Furthermore, episodic GH release evident in SOC animals was obliterated after hypothalamic deafferentation. PRL concentrations in peripheral serum of hypothalamic deafferentated gilts remained similar (P greater than 0.05) to those of SOC animals. These results indicate that anterior and posterior hypothalamic neural pathways play a minor role in the control of PRL secretion in the pig in as much as PRL levels remained unchanged after hypothalamic deafferentation. These findings may be interpreted to suggest that the hypothalamus by itself seems able to maintain tonic inhibition of PRL release. In contrast, the maintenance of episodic GH secretion depends upon its...Continue Reading

Citations

Jan 1, 1996·Domestic Animal Endocrinology·C K Tuggle, A Trenkle
Jan 29, 2002·Animal Reproduction Science·H S SunC K Tuggle
Jun 2, 2005·Domestic Animal Endocrinology·L L AndersonA Glavaski-Joksimovic
Jul 2, 2004·Experimental Biology and Medicine·Jin-Sook LeeLloyd L Anderson

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