PMID: 2113997May 1, 1990Paper

Growth hormone and thyrotropin secretory profiles and provocative testing in aged rats

Neurobiology of Aging
W J MillardJ W Simpkins

Abstract

The impact of aging on both basal and induced GH and TSH secretion in male and female rats was investigated. Analysis of the individual GH secretory profiles in young (3-4 month) and old (19-20 month) rats indicated that sex-dependent patterns of GH secretion was preserved in old animals. However, we observed a reduction of individual GH peak amplitudes of 66% in old males and 53% in old females when compared to their respective young animals. Further, the GH response to an intravenous bolus of GH-releasing factor (GRF), morphine and clonidine was dramatically blunted or absent in old male and female animals. In contrast to GH, basal TSH secretion was elevated, while the TSH response to thyrotropin-releasing hormone (TRH) was not significantly affected in old animals of either sex. The present data provide evidence that reduced pituitary sensitivity to GRF may be a possible cause for reduced GH secretion in old animals. Further, the elevation in plasma TSH observed in old animals is not the result of an increased pituitary sensitivity to TRH.

References

Aug 1, 1978·The Journal of Endocrinology·H J Chen, P G Walfish
Jul 1, 1979·The Journal of Endocrinology·H J Chen, P G Walfish
Jan 1, 1985·Annual Review of Pharmacology and Toxicology·W B WehrenbergR Guillemin
Jan 1, 1985·Endocrine Reviews·J O JanssonO Isaksson
Aug 1, 1986·Endocrine Reviews·L A Frohman, J O Jansson
Oct 1, 1987·Klinicheskaia meditsina·S V German
May 1, 1987·The Journal of Clinical Endocrinology and Metabolism·A Vermeulen
Aug 1, 1987·Neuroendocrinology·S TakahashiJ Meites
Nov 1, 1986·Endocrinology·D O'SullivanR J Martin
Nov 1, 1972·The Journal of Clinical Endocrinology and Metabolism·J W FinkelsteinL Hellman
Jan 1, 1969·International Ophthalmology Clinics·P Cochet, H Amiard
Jan 1, 1981·Endocrine Reviews·J E Morley
Feb 1, 1983·Endocrinology·W J MillardJ B Martin
Sep 15, 1983·Biochemical and Biophysical Research Communications·W B Wehrenberg, N Ling
Nov 30, 1982·Biochemical and Biophysical Research Communications·W B WehrenbergR Guillemin
Feb 1, 1981·Mechanisms of Ageing and Development·J R FloriniJ P Weiss
Dec 1, 1980·Endocrinology·W E SonntagJ Meites

❮ Previous
Next ❯

Citations

Aug 1, 1992·Psychoneuroendocrinology·T F Sadow, R T Rubin
Jun 8, 2000·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·I ShimokawaS Lee
Jan 1, 1997·APMIS. Supplementum·P H Jørgensen
Nov 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Ravindra N Dhir, Bernard H Shapiro
Jul 1, 1991·Journal of Neuroimmunology·J B BaxterD A Weigent
May 26, 2006·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Jean D R TiongJohn J Kopchick
May 1, 1994·Journal of the American Geriatrics Society·S E BorstD T Lowenthal

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.