Growth Hormone Deficiency Is Frequent After Recent Stroke

Frontiers in Neurology
Thomas LillicrapAndrew Bivard

Abstract

Introduction: The incidence of pituitary dysfunction after severe ischemic stroke is unknown, however given the increasing attention to pituitary dysfunction after neurological injuries such as traumatic brain injury, this may represent a novel area of research in stroke. Methods: We perform an arginine and human growth hormone releasing hormone challenge on ischemic stroke patients within a week of symptom onset. Results: Over the study period, 13 patients were successfully tested within a week of stroke (baseline NIHSS 10, range 7-16). Overall, 9(69%) patients had a poor response, with 7(54%) of these patients meeting the criteria for had human growth hormone deficiency. Other measures of pituitary function were within normal ranges. Conclusion: After major ischemic stroke, low GH levels are common and may play a role in stroke recovery.

References

Jul 7, 2001·Neuroscience·A ScheepensC E Williams
Aug 3, 2005·European Journal of Endocrinology·Ginevra CorneliGianluca Aimaretti
Oct 11, 2005·Critical Care Medicine·Pejman CohanDaniel F Kelly
Jun 2, 2009·Behavioural Brain Research·Praneeti PathipatiArjan Scheepens
Jun 29, 2010·Journal of Neurotrauma·Walter M HighRandall J Urban
Jul 28, 2010·The Journal of Clinical Endocrinology and Metabolism·Marta BondanelliEttore C degli Uberti
May 1, 2013·Nature Reviews. Endocrinology·Atil Y Kargi, George R Merriam

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Citations

Jul 2, 2020·International Journal of Molecular Sciences·Sonia Sanchez-BezanillaLin Kooi Ong
Jul 6, 2020·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Fei WangGeorge C Wellman
Nov 26, 2019·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Kevin C J YuenAndrew R Hoffman
Jan 23, 2020·International Journal of Molecular Sciences·Sonia Sanchez-BezanillaLin Kooi Ong

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