PMID: 9642628Jun 27, 1998Paper

Growth hormone deficient children treated from before two years old fail to catch-up completely within five years of therapy

Journal of Pediatric Endocrinology & Metabolism : JPEM
T ArrigoF De Luca

Abstract

We retrospectively investigated growth response to therapy of 12 patients with idiopathic growth hormone deficiency (GHD), who received GH (0.6-0.7 IU/kg/week) in daily subcutaneous injections from before 2 years of age and for a period of 60 months, in order to ascertain whether very early treatment can enable GHD children to catch-up quickly and completely their initial height deficiency. The onset of therapy was followed in all patients during the 1st year by a significant growth spurt, which persisted, even though attenuated, during the following 4 years. Height deficiency for chronological age (CA) significantly and progressively decreased during the entire study period (from -3.7 +/- 1.9 to -1.0 +/- 1.0 SDS, p < 0.0025), with a cumulative height gain of 2.7 +/- 1.6 SDS. In spite of this catch-up growth no patient attained the target percentile by the 5th year of therapy and their average height (CA) was still lower with respect to the average target height (TH) at the last check-up. Because of the significant bone age (BA) delay still persisting in most patients, a further and complete catch-up growth is likely to occur during the next years of treatment, as suggested by the finding that average height (BA) at the last ex...Continue Reading

References

May 1, 1988·Archives of Disease in Childhood·P J SmithC G Brook
Dec 1, 1970·Archives of Disease in Childhood·J M TannerR H Whitehouse
Aug 1, 1958·The Journal of Clinical Endocrinology and Metabolism·M S RABEN

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Citations

Jun 17, 2015·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Keren SmuelZvi Laron
Dec 7, 2006·European Radiology·Olympia PapakonstantinouNicholas Gourtsoyiannis
Nov 22, 2001·Journal of Endocrinological Investigation·D Tiosano, Z Hochberg
Jan 22, 2018·Journal of Pediatric Endocrinology & Metabolism : JPEM·Semra ÇetinkayaFeyza Darendeliler

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