PMID: 2125608Dec 1, 1990Paper

Growth hormone enables effective nutrition by peripheral vein in postoperative patients: a pilot study

Journal of the American College of Nutrition
S L LehmannF B Cerra

Abstract

The purpose of this pilot study was to investigate the metabolic effects of growth hormone (GH) (Humatrope, Eli Lilly & Co., Indianapolis, IN) administration in postoperative (PO) patients receiving peripheral vein nutrition. Seven, well-nourished, nondiabetic patients undergoing elective surgical procedures were given either no drug (n = 3), GH 30 micrograms/kg/day (n = 2), or GH 60 micrograms/kg/day (n = 2) sub-Q daily until eating, up to 7 days PO. All the patients received 5% dextrose with electrolytes in the first 24 hours PO and then received calories at 80 +/- 5% of the measured resting energy expenditure (REE) and amino acid at 1 g/kg/day with electrolytes, vitamins, and minerals. There were no significant outcome differences between the 30 and 60 micrograms/kg/day groups and, therefore, these groups were analyzed together (n = 4). By day 6 of the study, the GH group had a significant reduction in the respiratory quotient (RQ) measured by indirect calorimetry; an increase in nitrogen retention; an increase in plasma transferrin concentrations; and an increase in plasma insulinlike growth factor (IGF1) concentration. There was no increase in blood glucose concentrations, or decrease in urinary 3-methylhistidine excretion...Continue Reading

Citations

Mar 1, 1993·World Journal of Surgery·J Yee, N V Christou
Oct 29, 2011·World Journal of Surgery·Travis M Polk, C William Schwab
Aug 1, 1992·Digestive Diseases and Sciences·S A McClaveH L Snider
Jul 16, 2008·Intensive Care Medicine·Paul E Marik, Gary P Zaloga
Oct 1, 1995·Clinical Endocrinology·J NygrenO Ljungqvist
Feb 1, 1992·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·S Lehmann, F B Cerra
Jul 18, 2001·Current Opinion in Clinical Nutrition and Metabolic Care·C A RagusoC Pichard
Jul 1, 1993·The Journal of Pediatric Endocrinology·J J Chipman
Feb 1, 1995·The Annals of Pharmacotherapy·T W MattoxP G Cuddy

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