Growth hormone excess and sexual precocity in polyostotic fibrous dysplasia (McCune-Albright syndrome): evidence for abnormal hypothalamic function.

The Journal of Pediatrics
E S LightnerS D Frasier

Abstract

A 5-5/12-year-old boy with gigantism and precocious puberty associated with the McCune-Albright syndrome is presented. Serum concentrations of growth hormone were extremely elevated (128-163 ng/ml) and were not suppressed by hyperglycemia or chlorpromazine. Serum LH (7.4 +/- 1.0 SD mIU/ml) and FSH (5.3 +/- 0.3 SD mIU/ml) concentrations were in the range observed in midpuberty. The secretion pattern of LH was episodic. The administration of estradiol suppressed the secretion of FSH and had an apparent positive feedback effect on release of LH. These findings are compatible with abnormal hypothalamic function as the mechanism for the endocrinopathies associated with the McCune-Albright syndrome.

References

Sep 1, 1973·The Journal of Pediatrics·G CostinM D Kogut
Sep 21, 1972·The New England Journal of Medicine·R BoyarL Hellman
Dec 1, 1972·The Journal of Clinical Endocrinology and Metabolism·H E Kulin, E O Reiter
Jul 1, 1974·The Journal of Clinical Endocrinology and Metabolism·A Johanson
Sep 1, 1970·The Journal of Clinical Endocrinology and Metabolism·A M LawrenceL Kirsteins
Nov 1, 1970·The Journal of Clinical Endocrinology and Metabolism·K NakagawaK Mashimo
Jan 14, 1971·The New England Journal of Medicine·L ShermanH D Kolodny
Apr 15, 1971·The New England Journal of Medicine·H D KolodnyF Benjamin
Mar 1, 1969·The Journal of Pediatrics·A J JohansonR M Blizzard
Mar 1, 1969·The Journal of Clinical Endocrinology and Metabolism·P E Cryer, W H Daughaday
Apr 1, 1966·American Journal of Diseases of Children·P H Benedict
Mar 1, 1967·The Journal of Clinical Endocrinology and Metabolism·C Faiman, R J Ryan
Feb 1, 1949·Proceedings of the Royal Society of Medicine·G P ARDEN

❮ Previous
Next ❯

Citations

Mar 1, 1991·Pediatric Dermatology·J G Roth, N B Esterly
Apr 1, 1991·Journal of Endocrinological Investigation·C MannaR Canipari
Apr 1, 1985·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·C A Waldron
Jul 1, 1976·The Journal of Pediatrics·E S LightnerS D Frasier
Jul 1, 1976·The Journal of Pediatrics·S K Joishy, L B Morrow
May 1, 1978·The Journal of Pediatrics·N S Halmi, T M Duello
Apr 1, 1983·The Journal of Pediatrics·M D'ArmientoL Tardella
May 1, 1981·Clinical Endocrinology·J Albin, R Wu
Nov 1, 1991·American Journal of Medical Genetics·M EndoN Niikawa
Nov 1, 1990·American Journal of Medical Genetics·R N Schimke
Oct 17, 2007·Journal of Pediatric Endocrinology & Metabolism : JPEM·Alejandro DiazJohn Crawford
Sep 1, 1982·Journal of Endocrinological Investigation·C PolychronakosR Collu
Apr 29, 2004·Journal of Pediatric Endocrinology & Metabolism : JPEM·Chun-Jung ChenYeong-Seng Yuh
Oct 1, 1989·Scottish Medical Journal·S J GallacherJ A Thomson
Mar 1, 1992·Journal of Endocrinological Investigation·S I Sherman, P W Ladenson
Jun 23, 2006·Journal of Pediatric Endocrinology & Metabolism : JPEM·Malgorzata WasniewskaUNKNOWN Italian Study Group for Alterations of Gs alpha Protein Function
Jun 23, 2006·Journal of Pediatric Endocrinology & Metabolism : JPEM·Athanasios ChristoforidisRichard Stanhope

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here