Growth hormone (GH) action in the brain: neural expression of a GH-response gene

Journal of Molecular Neuroscience : MN
Steve HarveyM Pines

Abstract

The presence of growth hormone (GH) binding sites and GH-receptor (GHR)-immunoreactive proteins in the brain suggests it is a target site for GH action. This could, however, reflect the presence of GH-binding proteins (GHBP) that are not linked to intracellular signal-transduction mechanisms, rather than authentic receptors. The possibility that GH has actions in the brain therefore has been examined by determining an intracellular mediator of GH action. The mechanism of GH action involves the induction of a number of specific GH-response genes. In chickens, a novel GH-responsive gene (GHRG-1) has been identified as an intracellular marker of GH action, since this gene is not expressed in GH-resistant dwarfs with dysfunctional GHRs and in normal chickens it is upregulated by exogenous GH. In normal chickens GHRG-1 mRNA is also abundant and widespread in the brain. In the cerebellum it is specifically localized in the cerebellar folia. It is present in most cells in the granular layers of the gray matter but is present in only a small number of scattered cells in the molecular layer and white matter. Intense labeling for GHRG-1 mRNA is also present in the large Purkinje cells and their dendrites at the interface between the mole...Continue Reading

Citations

Jul 28, 2005·Cell and Tissue Research·Jason A BeyeaSteve Harvey
Apr 6, 2005·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·M Bohlooly-YE Omerovic
Aug 14, 2003·Journal of Virology·Martha F KramerDonald M Coen
Feb 5, 2013·General and Comparative Endocrinology·Steve Harvey
Aug 28, 2012·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Faezeh KoohestaniEsmail Meisami
Feb 17, 2007·General and Comparative Endocrinology·Steve HarveyEsmond J Sanders
May 22, 2009·Annals of the New York Academy of Sciences·Steve HarveyEsmond J Sanders
Mar 17, 2015·Molecular Reproduction and Development·Makhsud Tagirov, Serguei Golovan
Jan 27, 2018·International Journal of Molecular Sciences·Carlos G Martínez-MorenoJosé Luis Quintanar
Oct 26, 2010·Endocrine·S Harvey
Jan 28, 2006·Hormone Research·Arjan ScheepensPeter D Gluckman
Jan 27, 2019·Cerebellum & Ataxias·Kelsey JensenAasef G Shaikh
May 29, 2003·Canadian Journal of Physiology and Pharmacology·S HarveyE J Sanders
Jan 10, 2021·American Journal of Medical Genetics. Part a·Liane BourcierMouna Ben Amor
Jun 3, 2021·International Journal of Molecular Sciences·Margarita HerediaAdelaida Sánchez Riolobos

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