PMID: 9529182Apr 7, 1998Paper

Growth hormone improves the resistance of thermally injured mice infected with herpes simplex virus type 1

The Journal of Trauma
K TakagiD N Herndon

Abstract

Growth hormone (GH) has been shown to promote wound healing and to improve protein metabolism in burned patients. Through immunomodulation, GH has also protected rats infected with Salmonella typhimurium and mice infected with Escherichia coli. In spite of advances in the management of patient care for those with thermal injuries, high mortality rates of burned patients as a result of infections are of special concern. An improvement in the resistance of burned patients to certain infections will make the beneficial role of GH very clear. In this study, therefore, the immunomodulating effects of recombinant human GH (rhGH) in thermally injured mice exposed to opportunistic herpesvirus infections were investigated. (1) Burned mice, exposed to herpes simplex virus type 1 (HSV-1), were treated subcutaneously with rhGH (4 mg/kg) and observed for 21 days to determine the protective antiviral effect of rhGH. (2) Because of reports describing a lack of interferon-gamma (IFN-gamma) responsiveness in burned mice, the IFN-gamma-producing ability of the splenic mononuclear cells (SMNC) from burned mice treated with rhGH was examined. (3) Because the generation of burn-associated suppressor macrophages that can inhibit the IFN-gamma produc...Continue Reading

References

Feb 1, 1979·The Journal of Clinical Investigation·C L Miller, C C Baker
Dec 1, 1992·Brain, Behavior, and Immunity·C J WiedermannH Braunsteiner
Mar 11, 1992·The Journal of Burn Care & Rehabilitation·D J Smith, P D Thomson
Oct 1, 1991·Immunology Today·P Scott, S H Kaufmann
Nov 1, 1990·JPEN. Journal of Parenteral and Enteral Nutrition·T R ZieglerD W Wilmore
Nov 1, 1987·The Journal of Burn Care & Rehabilitation·G P KealeyR M Massanari
Apr 1, 1987·The Journal of Trauma·F Suzuki, R B Pollard
Jan 1, 1985·The Journal of Trauma·R J KaganO M Jonasson
Jun 1, 1987·Current Problems in Surgery·D N HerndonR E Barrow
Mar 19, 1970·The New England Journal of Medicine·F D FoleyB A Pruitt
Oct 1, 1984·The Journal of Trauma·J B O'MahonyJ A Mannick
Jan 1, 1980·Annals of Surgery·P W CurreriG T Shires
Jan 1, 1994·Trends in Microbiology·G Del Prete, S Romagnani
Jan 1, 1996·Annals of Surgery·T T NguyenD N Herndon
Jun 1, 1997·Immunology Today·S Romagnani

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Citations

Feb 5, 2004·Brain, Behavior, and Immunity·Keith W Kelley
Jun 5, 2003·Burns : Journal of the International Society for Burn Injuries·Hiroyuki KobayashiFujio Suzuki
May 15, 2008·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Marc G JeschkeDavid N Herndon
Dec 1, 2001·Expert Opinion on Biological Therapy·K N Masihi
Nov 21, 2007·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Daniel SchmitzReiner Oberbeck
Mar 27, 2001·The Journal of Surgical Research·T UtsunomiyaF Suzuki
Jun 9, 2004·Lancet·David N Herndon, Ronald G Tompkins
Sep 14, 1999·JPEN. Journal of Parenteral and Enteral Nutrition·T TashiroN Nakajima
Jan 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tatsushi KatakuraFujio Suzuki

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