PMID: 8603761Apr 1, 1996Paper

Growth hormone-induced insulin resistance and its relationship to lipid availability in the rat

Diabetes
M HettiarachchiE W Kraegen

Abstract

The role of increased lipid availability in the generation of insulin resistance by growth hormone has not been established. We investigated this in rats infused with saline (controls) or human growth hormone (hGH) (500 micrograms x kg-1 x 24 h-1) for 5 h or 3 days. hGH infusion increased basal plasma insulin at 5 h (335 +/- 33 vs. 197 +/- 15 [controls]; P < 0.005) and at 3 days (396 +/- 34 vs. 218 +/- 14 pmol/l; P < 0.0001). Plasma nonesterified fatty acid (0.26 +/- 0.01 vs. 0.21 +/- 0.01 [controls] g/l) and liver long-chain acyl-CoA (21.2 +/- 1.9 vs. 14.1 +/- 1.1 [controls] nmol/g wet wt) were elevated at 5 h (P < 0.01 for both) but were below control levels after 3 days of hGH infusion (P < 0.01 for both); indirect calorimetry after 3 days demonstrated decreased lipid oxidation. Clamp studies showed similar degrees of peripheral insulin resistance at 5-h and 3-day hGH infusion (glucose disposal reduced by 25% versus controls). Insulin-stimulated glucose metabolic index (Rg') in red gastrocnemius muscle (red muscle) was reduced (P < 0.05 and P < 0.01) at 5 h and 3 days of hGH infusion, respectively (e.g., 5 h, 10.0 +/- 1.8 vs. 24.1 +/- 4.4 [controls] micromol x 100 g-1 x min-1), whereas insulin-mediated muscle glycogen synthe...Continue Reading

Citations

Aug 5, 2000·Journal of Diabetes and Its Complications·M SuzukiY Harano
Sep 5, 2013·Animal Science Journal = Nihon Chikusan Gakkaihō·Tokushi KomatsuAkinori Oshibe
Feb 11, 2005·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·T JohansenK Malmlöf
Sep 29, 1998·Metabolism: Clinical and Experimental·S M ChalkleyE W Kraegen
Jul 27, 2001·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·S TakahashiM Hayakawa
Oct 29, 2000·American Journal of Physiology. Endocrinology and Metabolism·K S BellE W Kraegen
Jul 29, 2004·American Journal of Physiology. Endocrinology and Metabolism·Caroline AméenJan Oscarsson
May 29, 2000·American Journal of Physiology. Endocrinology and Metabolism·H E BøtkerO Schmitz
May 15, 2002·American Journal of Physiology. Endocrinology and Metabolism·Simon M ChalkleyEdward W Kraegen
Sep 4, 2019·American Journal of Physiology. Endocrinology and Metabolism·Pryscila D S TeixeiraJose Donato
Dec 31, 1997·The American Journal of Physiology·M HettiarachchiE W Kraegen
Nov 15, 1997·The American Journal of Physiology·S BanerjeeN Barzilai

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