PMID: 6987594Jan 1, 1980Paper

Growth hormone: mode of action on different varieties of cartilage (author's transl)

Pathologie-biologie
A Petrovic, J Stutzmann

Abstract

1) The growth of epiphyseal cartilages of long bones, of spheno-occipital synchondrosis of the cranial base, of the cartilage of the nasal septum, of lateral cartilaginous masses of the ethmoid, of cartilage between body and greater wings of the sphenoid (all stemming from the primary cartilaginous skeleton of the organism), is subject to general extrinsic factors and, more specifically, to the growth hormone (STH) and somatomedin. In this case, orthopedic devices can alterate the direction but not the amount of growth. 2) The growth of condylar, coronoid and angular cartilages of the mandible, of the cartilage of the midpalatal suture, and of the cartilage in some cranial sutures (all of secondary formation during phylogenesis and ontogenesis) is subject to local extrinsic factors as well as to growth hormone and somatomedin. In this case, appropriate orthopedic devices may modulate both the direction and the amount of growth. 3) Our cybernetic models attempt to account for the mechanisms of facial growth. By intensifying the forward growth of the nasal septum cartilage, the STH and somatomedin stimulate the forward growth of the upper jaw, i.e. the forward positioning of the superior dental arch (the position of which is the ...Continue Reading

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