Growth hormone modulates amino acid oxidation in the surgical patient: leucine kinetics during the fasted and fed state using moderate nitrogenous and caloric diet and recombinant human growth hormone

Metabolism: Clinical and Experimental
Franco CarliD Halliday

Abstract

Twelve patients (aged 70 +/- 9 years) who were scheduled for resection of rectosigmoid colon adenocarcinoma but were otherwise healthy were randomly allocated after surgery to receive either peripheral parenteral nutrition alone ([PPN] n = 6) or in combination with recombinant human growth hormone (rGH) at a daily dose of 0.15 U x kg(-1) x d(-1)(PPN + rGH, n = 6). The daily nutritional regimen was 0.1 g nitrogen x kg(-1) x d(-1) and 20 kcal x kg(-1) x d(-1) (nonprotein energy was supplied as 60% lipid and 40% carbohydrate), and it was maintained for 6 days before and 6 days after surgery. Protein kinetics were studied in all 12 patients during the fasted and fed states before and 6 days after surgery using an 8-hour 13C-leucine tracer infusion. Daily urinary nitrogen, gaseous exchange, and plasma insulin, growth hormone, and insulin-like growth factor-I (IGF-I) were determined before and after surgery. Surgery was responsible for significant increases in postabsorptive whole-body protein flux and synthesis and leucine oxidation (P < .01). Supplementation of PPN with rGH contributed to a significant attenuation of the postoperative increase in leucine oxidation (P = .02), with a significant increase in whole-body protein synthes...Continue Reading

References

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Citations

Sep 9, 2000·Nutrition·F Carli, T Schricker
Nov 15, 2002·Nutrition·Curtis J WrayPer-Olof Hasselgren
Aug 15, 2002·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Helene NørrelundNiels Møller
Nov 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·M J Rennie
Nov 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·S Welle
Jul 18, 2001·Current Opinion in Clinical Nutrition and Metabolic Care·C A RagusoC Pichard
Oct 20, 2004·Annals of Surgery·Thomas SchrickerFranco Carli
Oct 3, 2002·Anesthesiology·Thomas SchrickerFranco Carli
Jul 10, 2007·Metabolism: Clinical and Experimental·Thomas SchrickerFranco Carli
Mar 1, 2006·Journal of the European Academy of Dermatology and Venereology : JEADV·S B TekinS Altas
Dec 12, 2001·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·P V Carroll, G Van den Berghe
Jan 12, 2000·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·P V Carroll
Jan 22, 2002·Best Practice & Research. Clinical Endocrinology & Metabolism·P V Carroll
Jan 14, 2000·Electrophoresis·H Becker, C Gärtner
Aug 19, 2000·American Journal of Physiology. Endocrinology and Metabolism·T SchrickerF Carli
Feb 9, 2000·American Journal of Physiology. Endocrinology and Metabolism·N C JacksonA M Umpleby
Apr 26, 2000·American Journal of Physiology. Endocrinology and Metabolism·S ClaeyssensP Déchelotte
Oct 22, 2002·American Journal of Physiology. Endocrinology and Metabolism·Alberto BattezzatiLivio Luzi
Jul 27, 2000·American Journal of Physiology. Endocrinology and Metabolism·G BioloG Guarnieri

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