PMID: 18407191Mar 1, 1994Paper

Growth Hormone neuroregulation in diabetes mellitus

Trends in Endocrinology and Metabolism : TEM
A Giustina, W B Wehrenberg

Abstract

GH secretion is markedly altered in diabetic rats and humans. Diabetes in the rat, whether occurring spontaneously or after streptozotocin administration, results in depressed GH secretion. This defect is likely caused by an increase in hypothalamic somatostatin tone and decreased pituitary GH. The effects of diabetes in humans depend upon the etiology of the disease. In type-1 diabetes, GH secretion is increased and in type 2 it is decreased. Again, these changes are hypothesized to be due to opposite alterations in hypothalamic somatostatin. Current evidence suggests that GH hypersecretion in human type-1 diabetes may be relevant to important metabolic and angiopathic complications of the disease.

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Citations

Mar 1, 1995·Trends in Endocrinology and Metabolism : TEM·C Dieguez, F F Casanueva
Jan 1, 1996·Fundamental & Clinical Pharmacology·O BouillanneF Piette
Aug 26, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Leon A Bach, Lorna J Hale
Mar 11, 2011·Annals of the New York Academy of Sciences·Raul M LuqueRhonda D Kineman
Sep 1, 2004·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Jan Frystyk
Sep 1, 1996·Journal of Neuroscience Methods·J W LeidyW J Millard
Aug 15, 2014·Acta Diabetologica·Andrea GiustinaG Mazziotti
Apr 23, 2005·The Cochrane Database of Systematic Reviews·E VermeireA Lindenmeyer
Apr 30, 1999·Physiological Reviews·E E MüllerD Cocchi
Feb 9, 2017·Pituitary·Katharina SchilbachMartin Bidlingmaier
Jan 16, 2020·Archives of Endocrinology and Metabolism·Katharina Schilbach, Martin Bidlingmaier

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