PMID: 2429794Aug 1, 1986Paper

Growth hormone neurosecretory dysfunction

Clinics in Endocrinology and Metabolism
B B Bercu, F B Diamond

Abstract

The basis for understanding clinical disorders in the neuroregulation of GH secretion is derived from the complexity of the CNS-hypothalamic-pituitary axis. Studies in animals and humans demonstrate an anatomic, physiological and pharmacological evidence for neurosecretory control over GH secretion including neurohormones (GRH, somatostatin), neurotransmitters (dopaminergic, adrenergic, cholinergic, serotonergic, histaminergic, GABAergic), and neuropeptides (gut hormones, opioids, CRH, TRH, etc). The observation of a defect in the neuroregulatory control of GH secretion in CNS-irradiated humans and animals led to the hypothesis of a disorder in neurosecretion, GHND, as a cause for short stature. We speculate that in this heterogeneous group of children a disruption in the neurotransmitter-neurohormonal functional pathway could modify secretion ultimately expressed as poor growth velocity and short stature.

References

Feb 1, 1978·Journal of Neurology, Neurosurgery, and Psychiatry·R J ChalmersR N Nanda
Apr 1, 1978·Psychoneuroendocrinology·G M BrownP G Ettigi
Jan 1, 1976·European Journal of Pharmacology·N Subramanian, A H Mulder
Jul 1, 1979·Clinical Endocrinology·H N CohenG H Beastall
Jun 1, 1976·The Journal of Clinical Investigation·K ChiharaH Imura
Aug 1, 1978·The Journal of Clinical Endocrinology and Metabolism·A A KowarskiW H Daughaday
Nov 1, 1978·Archives of Disease in Childhood·P G SwiftD C Savage
Jan 1, 1979·The Journal of Clinical Endocrinology and Metabolism·M KouluS Dahlström
Aug 1, 1979·The Journal of Clinical Endocrinology and Metabolism·T M Duello, N S Halmi
Jan 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·E Straus, R S Yalow
Feb 1, 1979·Archives of General Psychiatry·J H SatterfieldT Blaschke
Apr 1, 1979·The Journal of Pediatrics·L C DickinsonM J Elders
Jul 1, 1979·The Journal of Clinical Endocrinology and Metabolism·D RudmanJ H Patterson
Oct 15, 1979·European Journal of Pharmacology·J EpelbaumC Kordon
Aug 1, 1978·Metabolism: Clinical and Experimental·A MasalaG Lotti
Nov 1, 1975·Pharmacology, Biochemistry, and Behavior·R M Knights, C A Viets
Mar 10, 1977·The New England Journal of Medicine·Y PatelS Reichlin
Apr 1, 1977·The Journal of Clinical Endocrinology and Metabolism·C Dacou-VoutetakisL Zannos-Mariolea
Jan 1, 1977·Journal of Neural Transmission·E Syvälahti, A Pekkarinen
Sep 1, 1977·The Journal of Clinical Endocrinology and Metabolism·F CavagniniG Girotti
Sep 1, 1977·Clinical Endocrinology·A MasalaL Devilla
Jul 1, 1976·Archives of Disease in Childhood·S M ShaletD Pearson
Jun 1, 1975·Endocrinology·M BrownsteinJ S Kizer
Sep 1, 1975·The Journal of Clinical Investigation·W B MendelsonW H Daughaday
May 1, 1985·The Journal of Clinical Endocrinology and Metabolism·M Ishibashi, T Yamaji
Mar 29, 1985·Biochemical and Biophysical Research Communications·F Reyl-DesmarsF N Zeytin
Jul 1, 1985·The Journal of Clinical Endocrinology and Metabolism·E MoyseA Enjalbert

❮ Previous
Next ❯

Citations

Mar 2, 2006·Pituitary·Ken H Darzy, Stephen M Shalet
Jan 1, 1988·Molecular Aspects of Medicine·M Wallis
Jun 1, 1987·The Journal of Pediatrics·B B Bercu
Jan 1, 1996·Fundamental & Clinical Pharmacology·O BouillanneF Piette
Jan 1, 1990·Acta Paediatrica Scandinavica. Supplement·M L GranadaL Audí
Apr 21, 2006·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Ken H Darzy, Stephen M Shalet
Dec 1, 1996·Journal of the American College of Nutrition·V Matkovic
Jan 1, 1987·Acta Paediatrica Scandinavica. Supplement·R J RossG M Besser
Sep 14, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Paolo RagoneseGiovanni Savettieri
May 19, 2012·Expert Review of Anticancer Therapy·Thozhukat Sathyapalan, Sanjay Dixit
Feb 8, 2007·The Journal of Clinical Endocrinology and Metabolism·Ken H DarzyStephen M Shalet
Oct 7, 2016·Journal of Pediatric Endocrinology & Metabolism : JPEM·Marion KesslerRichard Noto
Jun 1, 1988·Journal of Endocrinological Investigation·G DelitalaR Virdis
Apr 1, 1992·Journal of Endocrinological Investigation·R ValcaviI Portioli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.