Growth hormone receptor deficiency in humans associates to obesity, increased body fat percentage, a healthy brain and a coordinated insulin sensitivity.

Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society
J Guevara-AguirreAntonio W D Gavilanes

Abstract

We have shown that subjects with Laron syndrome (LS) due to growth hormone receptor deficiency (GHRD) and their relatives have comparable brain structure and function; moreover, the brain of individuals affected with GHRD appears like those of younger people. While the functionally absent growth hormone receptor and the diminished concentrations of the insulin-like growth factor-I have been associated to these findings, the role of the insulin-glucose axis is emerging as an unavoidable consideration when determining the aetiology of these observations. In consequence, we decided to search for the potential and discrete associations between the neurological findings and several parameters of carbohydrate metabolism that might exist in the subjects affected with GHRD. Individuals affected with GHRD were compared to relative controls. Besides standard measures of anthropometry, body composition and brain characteristics, the elements of the carbohydrate metabolism (CHO), including glucose, insulin, triacylglycerol and the free insulin growth factor binding protein 1 (IGFBP1) concentrations were determined. In addition, the correlations existing between the parameters of CHO and brain characteristics were established. Besides the p...Continue Reading

Citations

Oct 14, 2020·Reviews in Endocrine & Metabolic Disorders·Jaime Guevara-AguirreAntonio W D Gavilanes
Dec 15, 2020·Frontiers in Endocrinology·Ger J StrousJan A Mol
Mar 5, 2021·The World Journal of Men's Health·Andrzej BartkeMichal M Masternak
Oct 15, 2020·Molecular and Cellular Endocrinology·Jaime Guevara-AguirreAntonio Wd Gavilanes

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