Growth hormone receptor gene deficiency causes delayed insulin responsiveness in skeletal muscles without affecting compensatory islet cell overgrowth in obese mice.

American Journal of Physiology. Endocrinology and Metabolism
Katie RobertsonJun-Li Liu

Abstract

Growth hormone (GH), acting through its receptor (GHR), is essential for somatic growth and development and maintaining metabolic homeostasis. GHR gene-deficient (GHR(-/-)) mice exhibit drastically diminished insulin-like growth factor-I (IGF-I) levels, proportional growth retardation, elevated insulin sensitivity, and reduced islet beta-cell mass. Unlike the liver, which is mostly unaffected by changes in IGF-I level, skeletal muscles express high levels of IGF-I receptor (IGF-IR). The net result of a concurrent deficiency in the actions of both GH and IGF-I, which exert opposite influences on insulin responsiveness, has not been evaluated. We studied insulin-stimulated early responses in the insulin receptor (IR), insulin receptor substrate-1 (IRS-1), and p85 subunit of phosphatidylinositol 3-kinase. Upon in vivo insulin stimulation, skeletal muscles of GHR(-/-) mice exhibit transient delayed responses in IR and IRS-1 phosphorylation but normal levels of p85 association with IRS-1. This is in contrast to normal/elevated insulin responses in hepatocytes and indicates tissue-specific effects of GHR gene deficiency. In addition to stimulating normal islet cell growth, GH may participate in islet cell overgrowth, which compensate...Continue Reading

References

Jan 1, 1989·Molecular Endocrinology·J H NielsenO D Madsen
Jan 1, 1994·Hormone Research·Z Laron, B Klinger
Mar 1, 1996·Journal of Internal Medicine·A Sjöholm
Oct 1, 1996·Endocrine Reviews·J R FloriniS A Coolican
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·A Z ZhaoJ A Beavo
May 15, 1997·The Journal of Clinical Investigation·G Di ColaD Accili
Jul 1, 1997·Diabetologia·M F White
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·Y ZhouJ J Kopchick
Mar 6, 1999·Endocrinology·V ChandrashekarJ J Kopchick
Apr 8, 1999·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M ScacchiF Cavagnini
Jun 1, 2000·Journal of Molecular Endocrinology·C J Rhodes
Jun 1, 2000·Endocrinology·S Bonner-Weir
Jun 30, 2000·Endocrinology·K T CoschiganoJ J Kopchick
Mar 29, 2001·Diabetes·S Bonner-Weir
Mar 29, 2001·Diabetes·J H NielsenC Carlsson
May 30, 2001·Diabetes Research and Clinical Practice·Y OkudaJ B Field
Apr 3, 2003·European Journal of Endocrinology·John J Kopchick
Jul 17, 2003·The Journal of Clinical Investigation·Christian WolfrumMarkus Stoffel
Jul 24, 2003·Mechanisms of Ageing and Development·Fernando P DominiciDaniel Turyn
Dec 23, 2003·The International Journal of Biochemistry & Cell Biology·Rohit N Kulkarni
Jan 1, 2004·The Journal of Clinical Investigation·David R Clemmons
May 13, 2004·American Journal of Physiology. Endocrinology and Metabolism·Jun-Li LiuYe Lauren Liu
Jul 24, 2004·American Journal of Physiology. Endocrinology and Metabolism·Lorna M Dickson, Christopher J Rhodes
Apr 16, 2005·Molecular and Cellular Biology·Jake A KushnerMorris F White

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Citations

Sep 6, 2008·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jorge F GianiFernando P Dominici
Jul 22, 2010·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Ercüment AksakalDeniz Ekinci
Oct 6, 2009·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Archana VijayakumarDerek LeRoith
Jan 22, 2009·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Laura VerganiGabriella Gallo
Sep 29, 2012·Proteomics·Juan DingJohn J Kopchick
Dec 23, 2014·Diabetes/metabolism Research and Reviews·Eyal J ScheinmanDerek LeRoith
May 6, 2015·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Jose Cordoba-ChaconRhonda D Kineman
Sep 7, 2017·Muscle & Nerve·Rylie M Hightower, Matthew S Alexander
Feb 1, 2007·American Journal of Physiology. Endocrinology and Metabolism·Jeffrey S DaviesTimothy Wells
Nov 30, 2019·Nature Reviews. Endocrinology·John J KopchickJens O L Jorgensen
Sep 22, 2017·International Journal of Molecular Sciences·Darlene E Berryman, Edward O List
Oct 11, 2020·Reviews in Endocrine & Metabolic Disorders·Jonathan YoungDarlene E Berryman

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