Growth hormone-releasing hormone and clonidine stimulate biosynthesis of growth hormone in neonatal pituitaries

Biochemical and Biophysical Research Communications
M G CozziE E Müller


Comparative studies were performed to verify the effect of growth hormone releasing hormone (GHRH) or clonidine (CLON), a compound thought to act via release of endogenous GHRH, in stimulating GH biosynthesis in the pituitary from neonatal and adult rats. In vitro preincubation for 1 h with GHRH (hpGRF-40, 10(-8) M) increased the incorporation of L-[3H]leucine in the electrophoretic band of GH in the pituitary from 10-day-old rats, but not in the gland from adult rats. Ex-vivo treatment with GHRH or CLON for 5 days was effective in stimulating GH biosynthesis only in the pituitary from neonatal rats. These data demonstrate that neonatal somatotropes are particularly sensitive to the GH-synthesizing activity of GHRH or a GHRH-releasing stimulus.


Jan 3, 1985·The New England Journal of Medicine·M O ThornerR M Blizzard
Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G G GickC Bancroft


Jan 1, 1993·The Journal of Pediatric Endocrinology·E E MüllerF Camanni
Apr 30, 1999·Physiological Reviews·E E MüllerD Cocchi

Related Concepts

Age Factors
Pituitary Stalk
Recombinant Growth Hormone
Human Pancreatic Growth Hormone-Releasing Factor
Rats, Laboratory
In Vitro [Publication Type]

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