Growth hormone-releasing peptide 6 prevents cutaneous hypertrophic scarring: early mechanistic data from a proteome study.

International Wound Journal
Maday Fernández-MayolaJorge Berlanga-Acosta

Abstract

Hypertrophic scars (HTS) and keloids are forms of aberrant cutaneous healing with excessive extracellular matrix (ECM) deposition. Current therapies still fall short and cause undesired effects. We aimed to thoroughly evaluate the ability of growth hormone releasing peptide 6 (GHRP6) to both prevent and reverse cutaneous fibrosis and to acquire the earliest proteome data supporting GHRP6's acute impact on aesthetic wound healing. Two independent sets of experiments addressing prevention and reversion effects were conducted on the classic HTS model in rabbits. In the prevention approach, the wounds were assigned to topically receive GHRP6, triamcinolone acetonide (TA), or vehicle (1% sodium carboxy methylcellulose [CMC]) from day 1 to day 30 post-wounding. The reversion scheme was based on the infiltration of either GHRP6 or sterile saline in mature HTS for 4 consecutive weeks. The incidence and appearance of HTS were systematically monitored. The sub-epidermal fibrotic core area of HTS was ultrasonographically determined, and the scar elevation index was calculated on haematoxylin/eosin-stained, microscopic digitised images. Tissue samples were collected for proteomics after 1 hour of HTS induction and treatment with either GHR...Continue Reading

References

Aug 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·K L SungL A Sung
Sep 1, 1997·Plastic and Reconstructive Surgery·D E MorrisT A Mustoe
Sep 26, 2002·Electrophoresis·Eugene C YiDavid R Goodlett
May 13, 2003·Journal of Endocrinological Investigation·M R A MartinsA M J Lengyel
Jun 18, 2003·Journal of Endocrinological Investigation·J H A OliveiraA M J Lengyel
Jul 26, 2005·Journal of Rehabilitation Medicine·Luc Vanden Bossche, Guy Vanderstraeten
Apr 21, 2006·Laboratory Investigation; a Journal of Technical Methods and Pathology·Takeshi TogoShigehiko Suzuki
Nov 2, 2006·Journal of Neurochemistry·Arancha Delgado-Rubín de CélixLaura M Frago
Oct 29, 2008·Laboratory Investigation; a Journal of Technical Methods and Pathology·JianFei WangUNKNOWN Wound Healing Research Group
Nov 14, 2008·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·B AlaioubiS Petersenn
Sep 23, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Kristina D O'ShaughnessyThomas A Mustoe
Oct 3, 2009·Journal of Cell Communication and Signaling·Hiromi YanagisawaRolf A Brekken
Nov 3, 2009·Vascular Pharmacology·Shobha GhoshJingmei Song
Nov 3, 2009·Biochemical and Biophysical Research Communications·Mika IkedaShigehiko Suzuki
Dec 1, 2009·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·B AlaioubiS Petersenn
Sep 18, 2012·Biochemical and Biophysical Research Communications·Youngsin Jung, Joseph H McCarty
Dec 6, 2012·International Journal of Endocrinology·Luís UvaPaulo Filipe
Feb 16, 2013·Current Rheumatology Reports·Alena Grebe, Eicke Latz
Nov 15, 2014·Archives of Plastic Surgery·Aurelia Trisliana PerdanasariPaolo Persichetti
Mar 27, 2015·European Journal of Immunology·Chrysothemis C Brown, Randolph J Noelle
Jun 23, 2015·International Journal of Cosmetic Science·N FurieI Tzchori
Oct 24, 2015·Journal of Cellular and Molecular Medicine·Dimitry A ChistiakovAlexander N Orekhov
Feb 4, 2016·Stem Cells International·Bommie Florence Seo, Sung-No Jung
May 21, 2016·Plastic Surgery International·Yssel Mendoza MaríJorge Berlanga Acosta
Jul 6, 2016·The British Journal of Dermatology·G C LimandjajaS Gibbs
Aug 31, 2016·Burns and Trauma·Zhensen ZhuEdward E Tredget
Jan 6, 2017·Cell Proliferation·Yongjing HeLi He
Feb 22, 2017·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Elif SariFatma Azize Budak Yildiran

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Citations

Apr 25, 2020·International Journal of Molecular Sciences·Claudia C DarmawanJe-Ho Mun

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