PMID: 2492934Jan 1, 1989Paper

Growth hormone response to diazepam, clonidine and glucagon in patients with epilepsy

Epilepsy Research
P M CrawfordD Chadwick

Abstract

The differing actions of phenytoin, carbamazepine and sodium valproate on growth hormone release were studied in 20 patients with recently diagnosed epilepsy using diazepam, clonidine and glucagon as stimulatory tests of growth hormone response. The results are compared with the growth hormone response obtained pre treatment, and those from 20 control patients and 11 patients with chronic treated epilepsy. There was a reduction in growth hormone response to diazepam in both treated and untreated patients with epilepsy compared to controls. Treatment with phenytoin resulted in a significant increase in growth hormone release after diazepam and glucagon, whilst sodium valproate reduced the growth hormone response to diazepam.

References

Aug 1, 1978·Epilepsia·G E Slater, D Johnston
Jan 1, 1979·The Journal of Clinical Endocrinology and Metabolism·M KouluS Dahlström
Feb 7, 1977·European Journal of Pharmacology·A Quattrone, R Samanin
Nov 1, 1976·Neuropharmacology·S ConsoloH Ladinsky
Jan 1, 1982·Psychoneuroendocrinology·A N EliasM K Grossman
Jan 1, 1982·Progress in Neurobiology·A ChapmanJ C Vernieres
Jul 1, 1984·Journal of Neurology, Neurosurgery, and Psychiatry·R D'AlessandroA Baruzzi
Aug 1, 1980·The Journal of Allergy and Clinical Immunology·S H JosephsR H Buckley

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Citations

May 11, 1992·Pediatric Neurology·J S CookR P Hoffman
Sep 6, 2015·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Shu-Hao Wei, Wang-Tso Lee
Mar 17, 2010·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Hamed A El-KhayatEssam I Mohamed

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