Growth hormone responsive neural precursor cells reside within the adult mammalian brain.

Scientific Reports
Daniel G BlackmoreRodney L Rietze

Abstract

The detection of growth hormone (GH) and its receptor in germinal regions of the mammalian brain prompted our investigation of GH and its role in the regulation of endogenous neural precursor cell activity. Here we report that the addition of exogenous GH significantly increased the expansion rate in long-term neurosphere cultures derived from wild-type mice, while neurospheres derived from GH null mice exhibited a reduced expansion rate. We also detected a doubling in the frequency of large (i.e. stem cell-derived) colonies for up to 120 days following a 7-day intracerebroventricular infusion of GH suggesting the activation of endogenous stem cells. Moreover, gamma irradiation induced the ablation of normally quiescent stem cells in GH-infused mice, resulting in a decline in olfactory bulb neurogenesis. These results suggest that GH activates populations of resident stem and progenitor cells, and therefore may represent a novel therapeutic target for age-related neurodegeneration and associated cognitive decline.

References

Aug 31, 1987·Neuroscience Letters·F GossardG Morel
Dec 1, 1994·Acta Paediatrica. Supplement·Q ZhaiF Nyberg
Aug 20, 1993·Brain Research. Developmental Brain Research·P E LobieM J Waters
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·Y ZhouJ J Kopchick
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·F DoetschA Alvarez-Buylla
Jul 6, 2001·Cell·H M BlauJ M Weimann
Jul 7, 2001·Neuroscience·A ScheepensC E Williams
Nov 21, 2001·Nature Reviews. Neuroscience·H I Kornblum, D H Geschwind
Mar 19, 2002·Journal of Neuroscience Methods·N KeeJ M Wojtowicz
Oct 24, 2003·The Journal of Comparative Neurology·Jason P BrownH Georg Kuhn
Jan 20, 2004·The Journal of Comparative Neurology·John L MignoneGrigori Enikolopov
Apr 20, 2004·The European Journal of Neuroscience·Mark I RansomeAnn M Turnley
Oct 21, 2004·Nature Neuroscience·A Denise R GarciaMichael V Sofroniew
Dec 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Florian T MerkleArturo Alvarez-Buylla
Feb 15, 2005·Neurobiology of Aging·Iñigo AzcoitiaJesus A F Tresguerres
Apr 23, 2005·Nature Methods·Brent A Reynolds, Rodney L Rietze
May 26, 2005·Progress in Neurobiology·Jason G EmsleyJeffrey D Macklis
Jul 19, 2005·Annual Review of Neuroscience·Guo-li Ming, Hongjun Song
Aug 16, 2005·Endocrinology·Weihong PanAbba J Kastin
Jul 1, 2006·Nature·Thomas A Rando
Aug 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kaylene M YoungWilliam D Richardson
Jan 16, 2008·Proceedings of the National Academy of Sciences of the United States of America·Volkan CoskunYi E Sun
Sep 2, 2008·Brain : a Journal of Neurology·Stefano PluchinoGianvito Martino
Nov 4, 2008·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·S McLenachanA M Turnley
Dec 18, 2008·Journal of Peptide Science : an Official Publication of the European Peptide Society·Roberto M AguilarLuis S Haro
Jun 27, 2009·Annual Review of Neuroscience·Arnold Kriegstein, Arturo Alvarez-Buylla
Mar 16, 2011·Journal of Visualized Experiments : JoVE·Hassan AzariBrent A Reynolds

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Citations

Oct 16, 2012·Acta Pharmacologica Sinica·Pooya Dibajnia, Cindi M Morshead
Dec 5, 2012·PloS One·Daniel G BlackmorePerry F Bartlett
Feb 18, 2016·Stem Cells International·Citlalli Regalado-SantiagoElisa Tamariz
Mar 16, 2013·The Journal of Pharmacy and Pharmacology·Harriët SchellekensJohn F Cryan
Apr 16, 2016·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Steve Harvey, Carlos G Martinez-Moreno
Apr 14, 2016·Brain Structure & Function·Isadora C FurigoJose Donato
Jan 27, 2018·International Journal of Molecular Sciences·Carlos G Martínez-MorenoJosé Luis Quintanar
Sep 13, 2019·International Journal of Molecular Sciences·Carlos G Martinez-MorenoCarlos Arámburo
Nov 2, 2019·Investigative Ophthalmology & Visual Science·Thomas FlemingCarlos G Martínez-Moreno
Jun 25, 2013·The Journal of Endocrinology·Eva BaquedanoLaura M Frago
Jan 23, 2020·International Journal of Molecular Sciences·Sonia Sanchez-BezanillaLin Kooi Ong
May 26, 2021·Neurología : publicación oficial de la Sociedad Española de Neurología·I Zamora-BelloM L López-Meraz

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Methods Mentioned

BETA
PCR
dissection
Assay
FACS

Software Mentioned

Axiocam MRm
FlowJo

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