Growth hormone secretagogues: focus on the growth hormone-releasing peptides

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
V Locatelli, A Torsello

Abstract

This review systematically analyses recent knowledge of the biology of the growth hormone-releasing peptides. Many years before native GHRH had been isolated and sequenced, the synthesis of an enkephalin analog, devoid of any opioid activity but capable of specifically releasing GH from in vitro pituitaries, prompted the design of a number of structurally interrelated GHRPs with improved GH-releasing activity. Nowadays, GHRPs are the most effective GH-secretagogues known and could be used profitably in humans with GH hyposecretory disturbances to promote a pattern of GH secretion that mimics physiology in a better way than the exogenously administered GH.

Citations

Feb 5, 2011·Journal of Endocrinological Investigation·G AngelidisP Georgoulias
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Mar 19, 2003·Domestic Animal Endocrinology·T HashizumeM Kojima
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May 1, 2012·Reproductive Sciences·George AngelidisIoannis E Messinis
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