PMID: 3772658Nov 1, 1986Paper

Growth hormone secretion in patients with constitutional delay of growth and pubertal development

The Journal of Pediatrics
R LanesG Moncada

Abstract

Growth hormone levels were measured every 30 minutes during sleep over 9 hours in 20 prepubertal patients with constitutional delay of growth and puberty (CGD) and in 10 age-matched controls, all of whom had had normal GH responses to an orally administered dose of clonidine. We found no significant difference in the mean 9-hour overnight GH concentration between groups (4.5 +/- 1.8 ng/ml (mean +/- SD) in the CGD group, 4.4 +/- 2.8 ng/ml in the control group). Total GH output (258 +/- 99 U vs 222 +/- 135 U), total number of nocturnal GH pulses (3.6 +/- 0.8 vs 3.3 +/- 1.3), mean peak GH response during nocturnal sampling (13 +/- 1.2 ng/ml vs 13.2 +/- 1.3 ng/ml), and basal somatomedin C concentrations were not different in the children with growth delay and controls. We conclude that prepubertal patients with constitutional delay of growth and puberty secrete GH normally and do not seem to have any abnormality in GH regulation.

References

May 1, 1979·The Journal of Clinical Endocrinology and Metabolism·L P PlotnickA A Kowarski
Apr 1, 1979·Pediatric Research·M GourmelenF Girard
Mar 1, 1971·The Journal of Clinical Endocrinology and Metabolism·A KowarskiR M Blizzard
Jun 1, 1984·American Journal of Diseases of Children·S F SiegelA L Drash
May 4, 1984·JAMA : the Journal of the American Medical Association·B E SpiliotisB B Bercu

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Citations

Jul 1, 1990·European Journal of Pediatrics·A SartorioG Faglia
Jun 1, 1987·The Journal of Pediatrics·B B Bercu
Jul 1, 1989·Clinical Endocrinology·S M Shalet
Aug 1, 1995·European Journal of Pediatrics·M SperlichH P Schwarz
Jan 1, 1987·Acta Paediatrica Scandinavica. Supplement·D I Shulman, B B Bercu
Jan 1, 1997·Journal of Pediatric Endocrinology & Metabolism : JPEM·J FerrarisP Fainstein-Day
Jul 7, 1999·Journal of Pediatric Endocrinology & Metabolism : JPEM·S R Rose, G Municchi
Jul 7, 1999·Journal of Pediatric Endocrinology & Metabolism : JPEM·S R RoseV Hodnicak
Apr 11, 2021·Journal of Pediatric Endocrinology & Metabolism : JPEM·Camilia KamounAdda Grimberg

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