Growth Hormone Secretion Patterns in German Landrace (DL) Fetuses and Piglets Compared to DL Piglets with Inherited 1,25-Dihydroxyvitamin D3 Deficiency

Nutrients
Manfred MielenzN Parvizi

Abstract

The regulation of growth hormone (GH) release during prenatal development and during early postnatal life is not entirely clarified. In this study plasma GH concentrations in pigs with inherited pseudo vitamin D deficiency type I (PDDR-I), which regularly show growth retardation, were compared during ontogeny with unaffected pigs of the same breed (German Landrace, DL) as control. Plasma GH concentrations were measured in plasma of chronically catheterized fetuses (beginning on day 101 after mating or after artificial insemination) and in piglets (day 37 postpartum (p.p.)-day 42 p.p.) of both lines. A growth curve beginning at day 7 p.p. was recorded for both lines. The relative amount of GH receptor (GHR) mRNA in liver was quantified by competitive reverse transcription polymerase chain reaction in piglets at day 42 p.p. A trend for higher GH concentrations was observed in PDDR-I fetuses (p < 0.1). In PDDR-I piglets compared to DL piglets higher plasma GH values (p < 0.01), were observed despite lower body weight. The relative quantity of GHR mRNA in liver was not significantly different between the two lines. Piglets with an inherited defect of vitamin D synthesis showed higher GH concentrations. A hormonal imprinting by low ...Continue Reading

References

Jan 1, 1989·Journal of Perinatal Medicine·U Lachenmaier-Currle, J Harmeyer
Jan 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M J DaunceyD Cattaneo
Apr 1, 1996·The Journal of Endocrinology·M Bauer, N Parvizi
Aug 4, 1998·The American Journal of Physiology·B SchroederG Breves
Apr 30, 1999·Physiological Reviews·E E MüllerD Cocchi
Nov 24, 1999·Journal of Animal Science·R J HarrellD E Bauman
Aug 7, 2002·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·M J Waters, P L Kaye
Aug 14, 2003·The Journal of Nutritional Biochemistry·L S ChavezJ L Omdahl
Sep 11, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Reinhard BauerUlrich Zwiener
Mar 15, 2006·Mayo Clinic Proceedings·Michael F Holick
Aug 4, 2006·The Journal of Clinical Investigation·Michael F Holick
Sep 15, 2007·Nature Protocols·Lorena Zentilin, Mauro Giacca
Jun 9, 2009·Psychoneuroendocrinology·D W EylesT H J Burne
Jun 15, 2011·Seminars in Cell & Developmental Biology·Darryl EylesJohn McGrath
Sep 6, 2013·European Journal of Endocrinology·Pietro AmeriFrancesco Minuto
Jul 28, 2016·Neuroscience·Renata A N PertileDarryl W Eyles
Jun 24, 2017·BMC Public Health·Daniel SowahSebastian Straube
Jul 19, 2017·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·James P KesbyThomas H J Burne

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