Growth hormone stimulates bone healing in a critical-sized bone defect model

Clinical Orthopaedics and Related Research
L F H TheyseH A W Hazewinkel

Abstract

Growth hormone plays an important role in bone metabolism. Treating bone deficits is a major topic in orthopaedic surgery. Our hypothesis was that local continuous growth hormone administration stimulates bone healing in a canine critical-sized bone defect model. Bone formation in the defects was quantified using densitometric image analysis and histomorphometry. After growth hormone treatment, expression levels of insulin-like growth factors-I and II, and growth hormone receptor were determined in the bone regenerate of the original defects. Circulating plasma concentrations of insulin-like growth factors-I and II, and insulin- like growth factor binding proteins-4, and 6 were measured during treatment. Growth hormone administration resulted in healing of bone defects but without an additional effect of local infusion. Expression of insulin-like growth factor-I in the bone regenerate was lower in the growth hormone-treated dogs, whereas insulin-like growth factor-II and growth hormone receptor expression were not increased. Growth hormone increased circulating insulin-like growth factor-I and growth factor-II plasma concentrations. Continuous infusion of growth hormone stimulated bone healing in a canine critical-sized bone de...Continue Reading

References

Feb 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D EdwallG Norstedt
Aug 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P GeusensJ Dequeker
Jan 1, 1990·Metabolism: Clinical and Experimental·C M BautistaD J Baylink
Dec 1, 1981·Acta Endocrinologica·J E Eigenmann, R Y Eigenmann
Jun 10, 1994·Gene·J A Ascacio-Martínez, H A Barrera-Saldaña
Jun 1, 1996·The International Journal of Biochemistry & Cell Biology·K M KelleyR G Rosenfeld
Oct 1, 1996·Biology of Reproduction·R L de la SotaW W Thatcher
Dec 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E HednerA Nilsson
Jun 4, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M ThorénS Mohan
Sep 17, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R D WelchX J Li
Feb 17, 2000·The Journal of Veterinary Medical Science·S Fukuda, H Iida
Jun 9, 2001·Journal of Reconstructive Microsurgery·D A TiangcoJ K Terzis
Aug 2, 2001·The Journal of Endocrinology·R P FavierA Rijnberk
Dec 12, 2001·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·H J BailM J Raschke
Aug 7, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Evelien F GeversJan-Maarten Wit
Oct 12, 2002·American Journal of Physiology. Endocrinology and Metabolism·Craig A JaffePaul B Watkins
Nov 15, 2002·Molecular and Cellular Endocrinology·Jolle KirpensteijnJan A Mol
Jan 10, 2003·The Journal of Clinical Endocrinology and Metabolism·C EhrnborgUNKNOWN GH-2000 Study Group
May 23, 2003·Journal of Biomedical Materials Research. Part a·Stuart B GoodmanR Lane Smith
Jun 24, 2003·Journal of Animal Science·M A TryfonidouH A W Hazewinkel

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Citations

Jun 2, 2009·Expert Opinion on Investigational Drugs·Gui Tong TranEleftherios Tsiridis
Apr 24, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Jun YangBin Yu
Nov 21, 2009·Tissue Engineering. Part B, Reviews·Elizabeth A HornerXuebin B Yang

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