Growth hormone therapy in Turner syndrome--current uncertainties and future strategies

Hormone Research
M D Donaldson

Abstract

The effect of growth hormone (GH) on short-to-medium-term growth in girls with Turner syndrome is well-established. However, it is only relatively recently that final height data have become available. This paper reviews 10 reports from Europe (including Sweden, Austria, France, Holland, Belgium and Scotland), Canada, USA and Japan, on final height and near-final height in girls with Turner syndrome receiving GH therapy. An improvement in final height outcome versus projected adult height was found in all the studies, except for the Scottish study, in which the median final height was only 142.6 cm, and the Canadian study, in which the projected adult height was unexpectedly high at 148.2 cm. Although the mean final height was 150 cm or greater in six studies, all 10 showed considerable individual variation in final height with minimum values ranging between 131.5 and 145 cm. These results must be interpreted cautiously since the mean age of starting treatment was relatively late at 9.1-13.1 years. However, the overall modesty and interpatient variability of response to GH in Turner syndrome, and continuing uncertainty as to the role of oxandrolone and the timing of estrogen therapy, emphasizes the need for further research. Na...Continue Reading

Citations

Sep 17, 2004·The New England Journal of Medicine·Virginia P Sybert, Elizabeth McCauley
Feb 3, 2006·International Journal of Clinical Practice·A GawlikE Malecka-Tendera
May 23, 2006·Archives of Disease in Childhood·M D C DonaldsonD B Dunger
Aug 11, 2001·Lancet·M B Ranke, P Saenger
Jun 17, 2003·Clinical Endocrinology·Christopher J H Kelnar
Mar 25, 2004·American Journal of Medical Genetics. Part a·T R RohrerH G Doerr
Jan 27, 2007·The Cochrane Database of Systematic Reviews·L BaxterR Milne
Jan 17, 2008·The Journal of Clinical Endocrinology and Metabolism·Richard NisselUNKNOWN Pfizer International Growth Database (KIGS) International Board

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