Growth hormone treatment and aortic dimensions in Turner syndrome

The Journal of Clinical Endocrinology and Metabolism
Carolyn A BondyVincent B Ho

Abstract

In recent years many girls with Turner syndrome (TS) have been treated with supraphysiological doses of GH to increase adult height. In addition to promoting statural growth, GH may have direct effects on the cardiovascular system. We sought to determine whether GH treatment affects aortic diameter in girls with TS because there is an increased risk for aortic dilation and dissection in this syndrome. In a retrospective, cross-sectional study, we compared ascending and descending aortic diameters measured by magnetic resonance imaging in GH-treated (n = 53) vs. untreated (n = 48) patients with TS participating in a National Institutes of Health protocol between 2001 and 2004. The average duration of GH treatment was 4.7 with se 0.4 yr (range 2-11 yr). The two groups were similar in age and weight, but GH-treated subjects were on average 8 cm taller (P = 0.002). The diameter of the ascending aorta was increased by 7.3% and descending aorta by 8.9% in the GH-treated group. However, after correction for age, height, weight, and presence of bicuspid aortic valve and coarctation, using a multiple regression, neither history of GH treatment nor the length of GH treatment had an effect on the aortic diameter. Weight (P = 0.02), height...Continue Reading

References

Apr 1, 1986·Clinical Genetics·J A DelgadoV P Sybert
Jan 5, 2002·Journal of Developmental and Behavioral Pediatrics : JDBP·E McCauleyJ L Ross
Feb 19, 2002·Mechanisms of Ageing and Development·Annemarie Brüel, Hans Oxlund
Apr 5, 2002·The Journal of Clinical Endocrinology and Metabolism·Antonio CittadiniLuigi Saccà
Mar 12, 2003·The Journal of Clinical Endocrinology and Metabolism·Yvonne K van ParerenStenvert L S Drop
Sep 13, 2003·The Journal of Clinical Endocrinology and Metabolism·Dorothy I ShulmanRobert J Boucek
Oct 23, 2003·JAMA : the Journal of the American Medical Association·Margaret CooleyCarolyn A Bondy
Jul 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Vladimir K BakalovCarolyn A Bondy
Sep 2, 2004·European Journal of Endocrinology·A ColaoG Lombardi
Dec 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Julia E OstbergGerard S Conway
Jan 12, 2005·The American Journal of Cardiology·Moreno CecconiGian Piero Perna
Mar 24, 2005·The Journal of Clinical Endocrinology and Metabolism·David K Stephure, UNKNOWN Canadian Growth Hormone Advisory Committee
Mar 25, 2005·International Journal of Epidemiology·George Davey Smith
Jun 1, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Katherine C WoodD Neil Granger
Jun 22, 2005·Journal of Endocrinological Investigation·A M PasquinoD Larizza
Jul 7, 2005·The Journal of Clinical Endocrinology and Metabolism·Leandro Soriano-GuillenJean-Claude Carel

❮ Previous
Next ❯

Citations

Jul 5, 2006·Nihon rinsho. Japanese journal of clinical medicine·Noriyuki Katsumata
Jun 27, 2008·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Angela E LinBarbara R Pober
Mar 5, 2013·PloS One·Katya De GrooteDaniel De Wolf
Nov 15, 2013·European Journal of Endocrinology·Aneta Gawlik, Ewa Malecka-Tendera
Jul 8, 2008·Lancet·Jonathan Golledge, Kim A Eagle
May 23, 2007·The Journal of Pediatrics·Angela E Lin, Michael Silberbach
May 23, 2007·The Journal of Pediatrics·Lea Ann MaturaCarolyn A Bondy
Mar 6, 2007·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Luca LanzariniCatherine Klersy
Apr 1, 2008·Congenital Heart Disease·Carolyn A Bondy
Jan 23, 2013·Clinical Endocrinology·Iris Gutmark-Little, Philippe F Backeljauw
Apr 9, 2016·Journal of cardiology·Katya De GrooteJean De Schepper
May 30, 2015·Cardiology in the Young·Nassiba Alami LaroussiAnne Fournier
Apr 29, 2015·Clinical Radiology·A MarinS Mirsadraee
Oct 14, 2008·Archives of Cardiovascular Diseases·Yves DulacPhilippe Acar
Nov 9, 2016·European Journal of Pediatrics·Aisling M O'RiordanMichael J O'Grady
Dec 4, 2009·Expert Review of Cardiovascular Therapy·Joshua Thomas, Anji T Yetman
Apr 5, 2012·The Journal of Clinical Endocrinology and Metabolism·Jordan E Pinsker
Jun 19, 2012·Endocrine Reviews·Kristian H MortensenClaus H Gravholt
Nov 15, 2007·The Journal of Clinical Endocrinology and Metabolism·Katrina BolarBarbara Lippe
Mar 7, 2017·Turkish Journal of Medical Sciences·Hasan YiğitVehbi Doğan
Oct 26, 2018·Circulation. Genomic and Precision Medicine·Michael SilberbachUNKNOWN American Heart Association Council on Cardiovascular Disease in the Young; Council on Genomic and Precision Medicine; and Co
Jan 1, 2008·Expert Review of Endocrinology & Metabolism·Kateri McCarthy, Carolyn A Bondy
Nov 6, 2020·Journal of Pediatric Endocrinology & Metabolism : JPEM·Kamil DyrkaMarek Niedziela
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aortic Coarctation

Aortic coarctation is a congenital condition characterized by narrowing of the aorta. Discover the latest research on this disease here.