PMID: 7540478Jun 1, 1995Paper

Growth hormone treatment during pregnancy in a growth hormone-deficient woman

European Journal of Endocrinology
J MüllerN E Skakkebaek

Abstract

Information on the course and outcome of pregnancies in growth hormone (GH)-deficient patients is sparse, and GH treatment during pregnancy in such women has not been described previously. We have studied fetal growth and serum levels of GH, insulin-like growth factor I (IGF-I) and IGF binding protein 3 (IGFBP-3) during pregnancy, as well as birth weight and hormone levels after delivery in a 25-year-old woman with idiopathic, isolated GH deficiency diagnosed at the age of 7 years. As part of a clinical trial, the patient was treated with 2 IU/M2 GH for a period of 5 years. At this time she became pregnant after donor insemination. The GH treatment was continued until variant GH production from the placenta was evident. Serum levels of GH, IGF-I and IGFBP-3 were measured monthly during pregnancy after 3 days off GH therapy. Abdominal ultrasound was performed five times. Hormonal levels were measured immediately after delivery and during the following days. Serum GH and IGF-I levels increased during the second half of pregnancy; serum IGFBP-3 remained constant throughout pregnancy at a normal level. Serum levels of GH fell within 1 h after delivery, and levels of IGF-I and IGFBP-3 decreased into the range of GH-deficient women 4...Continue Reading

Citations

Jan 1, 2004·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Jens FuglsangPer Ovesen
Jun 4, 2002·Human Reproduction·Caroline E OvertonGerard S Conway
Aug 11, 2015·Fertility and Sterility·Greisa VilaAnton Luger
Jul 5, 2006·Clinical Endocrinology·R HallG S Conway
Aug 3, 2002·Clinical Endocrinology·Lena WirénGudmundur Johannsson
Dec 22, 2017·Journal of the Endocrine Society·Fernanda A CorreaLuciani R Carvalho
Nov 26, 2019·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Kevin C J YuenAndrew R Hoffman

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