Growth hormone treatment enhances the functional recovery of sciatic nerves after transection and repair

Muscle & Nerve
Pablo DevesaVíctor M Arce

Abstract

Although nerves can spontaneously regenerate in the peripheral nervous system without treatment, functional recovery is generally poor, and thus there is a need for strategies to improve nerve regeneration. The left sciatic nerve of adult rats was transected and immediately repaired by epineurial sutures. Rats were then assigned to one of two experimental groups treated with either growth hormone (GH) or saline for 8 weeks. Sciatic nerve regeneration was estimated by histological evaluation, nerve conduction tests, and rotarod and treadmill performance. GH-treated rats showed increased cellularity at the lesion site together with more abundant immunoreactive axons and Schwann cells. Compound muscle action potential (CMAP) amplitude was also higher in these animals, and CMAP latency was significantly lower. Treadmill performance increased in rats receiving GH. GH enhanced the functional recovery of the damaged nerves, thus supporting the use of GH treatment, alone or combined with other therapeutic approaches, in promoting nerve repair.

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Citations

Dec 20, 2012·Annals of Plastic Surgery·Taolin FangFeng Zhang
Mar 13, 2012·Hormones and Behavior·Jesús DevesaVíctor Arce
Dec 23, 2015·Neural Regeneration Research·Rafet ÖzayYusuf Şükrü Çağlar
Dec 3, 2014·Advanced Drug Delivery Reviews·Alessandro FaroniAdam J Reid
May 19, 2016·Expert Opinion on Therapeutic Targets·Sami H TuffahaGerald Brandacher
Jan 27, 2017·International Journal of Molecular Sciences·Jesús DevesaPablo Devesa
Nov 18, 2017·International Journal of Molecular Sciences·Vittorio Emanuele BianchiLaura Rizzi
Jan 19, 2018·International Journal of Molecular Sciences·Diego CaicedoJesús Devesa
Oct 25, 2016·Clinical Medicine Insights. Endocrinology and Diabetes·Jesús DevesaPablo Devesa
Jun 18, 2019·Drug Metabolism Reviews·Olimpiu Bota, Lucian Fodor
Mar 21, 2020·Journal of Computer Assisted Tomography·Xuewen FengJingzheng Fan
Dec 7, 2019·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Wesley C HymerWilliam J Kraemer
Apr 4, 2021·International Journal of Molecular Sciences·Joaquín Guerra Gómez, Jesús Devesa

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