Growth hormone treatment for growth hormone deficiency and idiopathic short stature: new guidelines shaped by the presence and absence of evidence

Current Opinion in Pediatrics
Adda Grimberg, David B Allen

Abstract

The Pediatric Endocrine Society recently published new guidelines for the use of human growth hormone (hGH) and human insulin-like growth factor-I (hIGF-I) treatment for growth hormone deficiency, idiopathic short stature, and primary IGF-I deficiency in children and adolescents. This review places the new guidelines in historical contexts of the life cycle of hGH and the evolution of US health care, and highlights their future implications. The new hGH guidelines, the first to be created by the Grading of Recommendations Assessment, Development and Evaluation approach, are more conservative than their predecessors. They follow an extended period of hGH therapeutic expansion at a time when US health care is pivoting toward value-based practice. There are strong supporting evidence and general agreement regarding the restoration of hormonal normalcy in children with severe deficiency of growth hormone or hIGF-I. More complex are issues related to hGH treatment to increase growth rates and heights of otherwise healthy short children with either idiopathic short stature or 'partial' isolated idiopathic growth hormone deficiency. The guidelines-developing process revealed fundamental questions about hGH treatment that still need ev...Continue Reading

References

Oct 23, 2003·The Journal of Pediatrics·Thomas A WilsonUNKNOWN Lawson Wilkins Pediatric Endocrinology Society Drug and Therapeutics Committee
Jan 9, 2010·The Journal of Clinical Endocrinology and Metabolism·David B Allen
Dec 17, 2011·The Journal of Clinical Endocrinology and Metabolism·Ron G RosenfeldJan M Wit
Jun 7, 2012·JAMA : the Journal of the American Medical Association·Patricia GabowGary Kaplan
Mar 29, 2013·The New England Journal of Medicine·David B Allen, Leona Cuttler
Jun 10, 2015·Scientific Reports·Adda GrimbergVirginia A Stallings
Jul 27, 2015·Pediatric Clinics of North America·David E Sandberg, Melissa Gardner
Oct 9, 2015·Hormone Research in Pædiatrics·Adda GrimbergKenneth R Ginsburg
Feb 27, 2016·The Journal of Clinical Endocrinology and Metabolism·Kerstin Albertsson-WiklandAnders Odén
Nov 25, 2016·Hormone Research in Pædiatrics·Adda GrimbergUNKNOWN Drug and Therapeutics Committee and Ethics Committee of the Pediatric Endocrine Society
Mar 3, 2017·Hormone Research in Pædiatrics·David B Allen

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Citations

Jan 27, 2019·International Journal of Environmental Research and Public Health·Laura PentaSusanna Esposito
Nov 16, 2019·American Journal of Medical Genetics. Part a·Shanlee DavisGhayda Mirzaa
May 29, 2020·The Cochrane Database of Systematic Reviews·Chin Fang NgimMeow-Keong Thong
Jul 13, 2019·Frontiers in Endocrinology·Roger PamphlettDavid P Bishop
Feb 7, 2020·Journal of Neuroscience Research·Tanika T WilliamsonRobert D Frisina
Oct 17, 2019·Frontiers in Endocrinology·João Soares FelícioJoão Felício Abrahão Neto
Oct 23, 2019·Journal of the Endocrine Society·Adda Grimberg, Genevieve P Kanter
Feb 15, 2020·Health Care Analysis : HCA : Journal of Health Philosophy and Policy·Maria Cristina Murano
Dec 21, 2020·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Kevin C J YuenNicky Kelepouris
Aug 22, 2021·Nature Reviews. Endocrinology·Camille HageRoberto Salvatori
Apr 2, 2020·Hormone Research in Pædiatrics·Talia HittAdda Grimberg
Jul 2, 2021·Indian Journal of Pediatrics·Rita Saroufim, Erica A Eugster

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