PMID: 8961129Sep 1, 1996Paper

Growth hormone treatment increases circulating lipoprotein(a) in children with chronic renal failure

Journal of Pediatric Endocrinology & Metabolism : JPEM
Z LaronD E Wilcken

Abstract

Cardiovascular disease is the major cause of death in chronic renal failure (CRF) patients managed by dialysis or kidney transplantation. Whilst the use of human growth hormone (hGH) is of established benefit in CRF children particularly in those with short stature, in the present study we assessed in CRF children the effect of hGH treatment on circulating lipoprotein(a) [Lp(a)], a genetically determined cardiovascular risk factor. We studied 15 CRF children treated by dialysis or conventional therapy and after kidney transplantation. Overnight fasting blood samples were collected immediately before and after 6 months hGH treatment. In all but one of the children there was a significant increase in serum Lp(a) over the 6 month treatment period -(+)66.7% over the basal levels (range 14 to 180%). After the hGH treatment, in six children Lp(a) levels were elevated to above 300 mg/l, the cut-off level for increased coronary artery disease (CAD) risk. Concomitantly/children also had an increase in serum levels of IGF-I (+96.4%) and insulin (+85.8%). All children had an accelerated growth velocity during the treatment; there was no effect on serum creatinine. Our study shows that hGH treatment in CRF children, though beneficial in it...Continue Reading

References

Apr 30, 1992·Clinica Chimica Acta; International Journal of Clinical Chemistry·X L WangN P Dudman
Sep 1, 1990·Acta Endocrinologica·Z LaronI Gil-Ad
Nov 17, 1989·Science·G Utermann
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Jun 1, 1995·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·I D SchwartzJ A Grunt
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Oct 1, 1995·Journal of Pediatric Endocrinology & Metabolism : JPEM·C T Cowell, S Dietsch

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Citations

Mar 29, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jeffrey M Saland, Henry N Ginsberg
Feb 12, 2004·Pediatric Transplantation·Philip D Acott, Jeffrey M Pernica
Oct 18, 2000·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Z Laron
Mar 28, 2007·Molecular and Cellular Biochemistry·Abdishakur M AbdulleJaipaul Singh

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