Growth hormone treatment of idiopathic short stature

Hormone Research
Raymond L Hintz

Abstract

Considerable controversy exists about the use of growth hormone (GH) treatment in short children without classical GH deficiency (idiopathic short stature or ISS). ISS is a multifactorial disorder with many potential causes rather than a single diagnostic entity, and it is in essence a diagnosis of exclusion. A careful investigation of the components of the GH/insulin-like growth factor (IGF) axis and other potential causes of short stature must be carried out in patients with significant short stature before they are categorized as having the ISS syndrome. As a group, most patients with ISS can be expected to attain an adult stature within the normal range. The ISS patients who will not do so are generally those who have a poor initial predicted adult height (PAH) and present at a younger age. Those ISS patients with a shorter midparental height are also less likely to achieve a normal adult height. In addition, several studies have shown that, as a group, males with ISS do not attain their initial PAH. Most studies on the GH treatment of patients with ISS have shown a short-term increase in growth rate and relative height. However, the long-term outcome of GH treatment of ISS has been variously reported to be no significant c...Continue Reading

Citations

May 2, 2002·Pediatrics International : Official Journal of the Japan Pediatric Society·Masahisa TakahashiKazuyoshi Watanabe
Jan 8, 2008·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·J M WitP Cohen
Mar 19, 2004·Sociology of Health & Illness·Peter Conrad, Deborah Potter
Jul 22, 2004·The Annals of Pharmacotherapy·Karen L Weise, Milap C Nahata

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