Growth impairment in children with extrahepatic portal vein obstruction is improved by mesenterico-left portal vein bypass

Journal of Pediatric Surgery
Timothy B LautzRiccardo A Superina

Abstract

Extrahepatic portal vein obstruction (EHPVO) has been associated with growth impairment in children. We hypothesized that growth parameters improve after reversal of portal hypertension and restoration of mesenteric venous blood flow to the liver by the mesenterico-left portal vein bypass (MLPVB). A retrospective review of 45 children with idiopathic EHPVO who underwent MLPVB between 1997 and 2007 and had follow-up data for analysis was carried out. Growth was assessed using SD scores (z scores) for height, weight, and body mass index (BMI) at the time of operation and at early (5-12 months) and late (13-24 months) follow-up. The mean height and weight of children with EHPVO was significantly lower than the general population before surgery. Mean BMI was also lower, although statistically insignificant. All parameters increased significantly after MLPVB as follows: height from -0.42 before surgery to -0.12 (P = .027) at 5 to 12 months and -0.14 (P = .026) at 13 to 24 months; weight from -0.49 before surgery to 0.03 (P < .001) at 5 to 12 months and 0.35 (P < .001) at 13 to 24 months; and BMI from -0.22 before surgery to 0.17 (P = .001) at 5 to 12 months and 0.48 (P < .001) at 13 to 24 months. Restoration of portal blood flow to ...Continue Reading

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Citations

Oct 12, 2013·Indian Journal of Pediatrics·Sundeep GoyalJayant Ghosh
Apr 1, 2014·Clinics in Liver Disease·Shiv K Sarin, Rajeev Khanna
Mar 11, 2015·Journal of Clinical and Experimental Hepatology·Radha K DhimanJang B Dilawari
Dec 12, 2013·Journal of the American College of Surgeons·Fabrizio di FrancescoJean de Ville de Goyet
Nov 28, 2012·Journal of the American College of Surgeons·Timothy B LautzRiccardo A Superina
Jul 18, 2012·Seminars in Pediatric Surgery·Lorenzo D'Antiga
Jul 18, 2012·Seminars in Pediatric Surgery·Jean de Ville de GoyetChiara Grimaldi
Mar 1, 2012·Journal of Vascular and Interventional Radiology : JVIR·Timothy B LautzRiccardo A Superina
Oct 31, 2015·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu
Aug 28, 2013·Journal of Hepatology·Rajeev Khanna, Shiv K Sarin
Apr 19, 2011·Journal of Pediatric Surgery·Timothy B LautzRiccardo A Superina
Nov 30, 2016·World Journal of Surgery·Ruo-Yi WangJin-Liang Li
Aug 21, 2014·Journal of Pediatric Gastroenterology and Nutrition·Lorenzo D'AntigaPiero Amodio
Jan 30, 2018·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Abdulrhman S ElnaggarJean C Emond
Jun 21, 2013·Journal of Pediatric Gastroenterology and Nutrition·Daniele AlbertiLorenzo D'Antiga
Sep 21, 2017·Frontiers in Pediatrics·Riten Kumar, Bryce A Kerlin
Sep 12, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Benjamin L ShneiderGeorge V Mazariegos
Jan 11, 2021·Pediatric Surgery International·Yu-Qing ZhangJuan Xiao

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