Growth in HIV-1-exposed but uninfected infants treated with lopinavir-ritonavir versus lamivudine: a secondary analysis of the ANRS 12174 trial

The Lancet. HIV
Stéphane BlancheANRS 12174 Trial Group

Abstract

The tolerance of antiretroviral drugs in infants must be carefully evaluated. In previous studies of children with HIV type 1 (HIV-1) less weight gain was observed in children given lopinavir-ritonavir-based combinations than those given nevirapine. We aimed to compare the effects of lopinavir-ritonavir and lamivudine on growth in HIV-exposed uninfected infants included in the ANRS 12174 trial. ANRS 12174 was a multicentre, randomised, controlled trial of infant prophylaxis to prevent HIV-1 transmission by breastfeeding done at four antenatal clinics in Burkina Faso, South Africa, Uganda, and Zambia. HIV-exposed uninfected infants born to asymptomatic mothers not eligible for antiretroviral therapy (CD4 count >350 cells per μL) were randomly assigned (1:1) to receive lopinavir-ritonavir or lamivudine 7 days after birth, with stratification by country. In a prespecified secondary analysis, we assessed the effect of lopinavir-ritonavir and lamivudine on the growth of these infants from day 7 until cessation of breastfeeding (maximum treatment time 12 months) in the modified intention-to-treat population, which included all children correctly enrolled with at least one follow-up anthropometric measurement. We compared the growth o...Continue Reading

References

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Citations

Oct 22, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Dulanjalee KariyawasamUNKNOWN ANRS 12174 Trial Group
Oct 21, 2019·Current HIV/AIDS Reports·Allison Ross EckardNancy L Hagood
Feb 19, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ana Montoya-FerrerEdouard Tuaillon
Mar 1, 2019·The Lancet. HIV·Kathleen M Powis, George K Siberry
Dec 4, 2020·Maternal & Child Nutrition·Aminata NdiayeMarie Reilly
Jun 3, 2021·Journal of Clinical Medicine·Audrey MonninJean-Pierre Molès

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