Growth in preterm infants fed either a partially hydrolyzed whey or an intact casein/whey preterm infant formula

Journal of Perinatology : Official Journal of the California Perinatal Association
K N FlorendoRichard J Cooke

Abstract

To compare feeding tolerance, nutrient intake and growth in preterm infants (< or =32 weeks, < or =1750 g) fed either a standard nonhydrolyzed whey-casein (nHWC) or a partially hydrolyzed whey (pHW) preterm infant formula. In this double-blind randomized controlled trial infants were fed either formula for at least 3 weeks. Intake was monitored daily, serum chemistries and growth weekly. Data were analyzed using analysis of covariance. A total of 80 infants were enrolled, 72 completed the study. No differences were noted in demographic characteristics. No differences were detected in feeding tolerance, intakes (118+/-21 vs 119+/-14; nHWC vs pHW) or growth weight, 28+/-1.5 vs 28+/-1.6 g per day; length, 1.0+/-0.7 vs 1.0+/-0.6 cm per week; head circumference, 0.9+/-0.4 vs 1.0+/-0.44 cm per week). At the end of study, blood urea nitrogen (5.2+/-3.1 <6.7+/-2.3 mg per 100 ml, nHWC<pHW), total serum proteins (4.7+/-0.4 >4.4+/-0.5 g per 100 ml) and albumin (2.7+/-0.3 >2.6+/-0.4 g per 100 ml) differed. A pHW preterm infant formula was not associated with improved feeding tolerance, enteral intake or growth but differences in serum chemistries. These are unlikely to be clinically relevant because values were well within normal limits fo...Continue Reading

References

Dec 1, 1994·Acta Paediatrica. Supplement·B Beaufrère
Feb 26, 2000·Clinics in Perinatology·S C Kalhan, S Iben
Jun 29, 2001·Journal of Pediatric Gastroenterology and Nutrition·J C PicaudB L Salle
Nov 29, 2002·Pediatrics·Walter A MihatschFrank Pohlandt
Oct 11, 2005·Acta Paediatrica. Supplement·Antonio A ZuppaGiuseppe Tortorolo
Sep 29, 2006·Journal of Perinatology : Official Journal of the California Perinatal Association·R J Cooke

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Citations

Feb 13, 2016·Archives of Disease in Childhood. Fetal and Neonatal Edition·Richard J Cooke
Sep 7, 2016·Seminars in Fetal & Neonatal Medicine·William W Hay, Kendra C Hendrickson
Oct 3, 2017·The Cochrane Database of Systematic Reviews·Derek Hang Cheong NgWilliam McGuire
Oct 30, 2015·Journal of Pediatric Gastroenterology and Nutrition·Yvan VandenplasWay S Lee
Jan 14, 2012·Journal of Pediatric Gastroenterology and Nutrition·Francesco RaimondiLetizia Capasso
Jul 25, 2019·The Cochrane Database of Systematic Reviews·Derek Hang Cheong NgWilliam McGuire
Jul 22, 2014·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Julie WagnerAnn Anderson-Berry
May 26, 2017·The Cochrane Database of Systematic Reviews·David A OsbornLisa J Jones
Oct 20, 2018·The Cochrane Database of Systematic Reviews·David A OsbornLisa J Jones
Aug 17, 2019·International Journal of Environmental Research and Public Health·Maria Elisabetta BaldassarreNicola Laforgia

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