PMID: 3771619Jan 1, 1986Paper

Growth inhibition of experimental glioma grafts by monoclonal antibody treatment

Journal of Cancer Research and Clinical Oncology
D StavrouP Mehraein

Abstract

The effects of 14AC1 monoclonal antibody (McAb) on 79FR-G-41 rat glioma cells in vitro, on the formation of metastases in lung by antibody coated glioma cells, and on the growth of glioma grafts in BALB/c-nu/nu mice were investigated. The 14AC1 antibodies - isotyped as IgG2a - were obtained from a hybridoma clone established after fusion of X63-Ag8.653 myeloma cells and spleen cells of BALB/c mice hyperimmunized with 79FR-G-41 glioma cells. Antibody treatment of glioma cells in vitro caused evident cell surface alterations and pronounced growth depression of most cells. However, a few tumor cells remained unchanged in morphology and continued to proliferate. Moreover, 14AC1 antibodies drastically reduced lung metastasis by pretreated and i.v. delivered glioma cells. Additionally, 14AC1 antibodies suppressed the growth of transplanted rat gliomas in nude mice as evidenced by a longer latency period and a smaller volume of glioma grafts in treated than in control tumor bearers. Nevertheless, glioma grafts showed accelerated growth after termination of antibody treatment. Further experimental investigation is required in order to identify the precise mechanisms of the effects of McAbs on tumor cells in vitro and in vivo.

References

Mar 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·I HellströmK E Hellström
Oct 1, 1983·European Journal of Cancer & Clinical Oncology·D StavrouN De Tribolet
Feb 11, 1983·Science·E S VitettaJ W Uhr
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·H P Vollmers, W Birchmeier
Nov 15, 1980·International Journal of Cancer. Journal International Du Cancer·D StavrouT Bilzer

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Citations

Jan 1, 1989·Cancer Chemotherapy and Pharmacology·M M Tomayko, C P Reynolds
Jan 1, 1990·Neurosurgical Review·D Stavrou
Jan 1, 1996·Cancer Chemotherapy and Pharmacology·J I ZwickerC P Reynolds
Sep 1, 1987·Journal of the Neurological Sciences·D StavrouU Stocker
Dec 1, 1989·Journal of Neuroimmunology·C de Micco
Jun 11, 2015·PloS One·Hermann B FrieboesVittorio Cristini
Jun 16, 2009·Seminars in Cancer Biology·Hans Petter Eikesdal, Raghu Kalluri
Oct 12, 2004·Hematology/oncology Clinics of North America·Benjamin Purow, Howard A Fine

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