Growth inhibition of myeloma cells by anti-idiotype antibodies in the absence of membrane-bound immunoglobulin

Immunology and Cell Biology
Shiri MoshitzkyNurit Hollander

Abstract

Immunoglobulins are expressed as membrane-bound or secreted forms. Plasma cells produce little or no membrane immunoglobulin but secrete immunoglobulin molecules in large amounts. Immunoglobulin idiotypes of malignant B cells are tumor-specific antigens that may be targeted for immunotherapy. Thus, idiotype vaccination is being evaluated in clinical trials to control residual disease in multiple myeloma and non-Hodgkin's lymphoma. It is traditionally considered that anti-idiotype antibodies are not effective against plasma cell tumors, because the large amounts of immunoglobulin molecules secreted by the tumors block anti-idiotype antibodies, and because the absence of membrane immunoglobulin on the surface of these tumor cells renders them resistant to the effect of anti-idiotype antibodies. While the obstacle of abundant circulating idiotype may be obviated by reducing tumor burden to minimal residual disease, the absence of membrane immunoglobulin has been considered as a limiting factor that prevents tumor eradication by anti-idiotype antibodies. We demonstrate here that murine plasmacytoma cells can produce small amounts of membrane immunoglobulin M (IgM) heavy chains. However, the latter are precursor molecules that do no...Continue Reading

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Citations

Jul 20, 2010·Immunotherapy·David S RitchiePaul Neeson
Sep 16, 2008·Best Practice & Research. Clinical Haematology·Jacalyn Rosenblatt, David Avigan
Feb 22, 2011·European Journal of Haematology·Marianne FrøylandBjarne Bogen
May 20, 2015·Cancer Immunology, Immunotherapy : CII·Katy J McCannChristian H Ottensmeier
Jan 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sharon CohenNurit Hollander

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