PMID: 2494120Mar 15, 1989Paper

Growth-inhibitory activity of interferon-beta against human colorectal carcinoma cell lines

International Journal of Cancer. Journal International Du Cancer
V L WongM A Anzano

Abstract

Recombinant human interferon beta (rIFN-beta) inhibited in a time- and dose-dependent manner the proliferation of 18/18 human colon carcinoma cell lines in monolayer culture and 8/9 lines in a soft agar assay but had no effect on 4 human fibroblast cell lines. Maximal inhibition of cell proliferation by rIFN-beta required repetitive treatment (every 2 days) with lymphokine (50 units/ml). Furthermore, the inhibitory activity of rIFN-beta was neutralized by polyclonal antibodies against natural IFN-beta. In contrast to rIFN-beta, rIFN-alpha was inactive against all colon cell lines tested, and rIFN-gamma, with the exception of HT-29 cells, was similarly ineffective. These data demonstrate that rIFN-beta is a potent growth inhibitor of colon carcinoma cells in vitro, and suggest that studies on its mechanism of action may lead to a better understanding of the regulation of colon tumor cell proliferation.

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Citations

Sep 9, 1996·Journal of Immunological Methods·A R Mire-SluisR Thorpe
Feb 21, 2006·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Fahao ZhangZhongyun Dong
Nov 4, 2004·Journal of the National Cancer Institute·Matus StudenyMichael Andreeff
Oct 27, 2009·Future Oncology·Raja Shekar Rachakatla, Deryl Troyer
Jan 1, 1991·Cancer Immunology, Immunotherapy : CII·S S SomersP J Guillou
Jul 12, 2011·Advanced Drug Delivery Reviews·Khalid Shah
Feb 9, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Takaya MatsuzukaMasaaki Tamura
Nov 23, 2007·Advanced Drug Delivery Reviews·M Ian Phillips, Yao Liang Tang
Jan 26, 2012·Journal of Cellular Biochemistry·Kalamegam GauthamanAriff Bongso
Jul 15, 1990·International Journal of Cancer. Journal International Du Cancer·J H Schiller, G Bittner
Nov 20, 2018·Frontiers in Immunology·Elisabeth MüllerAlexandre Corthay
Nov 19, 2021·Journal of Hematology & Oncology·Tianxia LanXiawei Wei

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