PMID: 2123126Dec 1, 1990Paper

Growth-inhibitory effect of combination chemotherapy for human pancreatic cancer cell lines

Cancer
S MatsunoS Akaishi

Abstract

Sensitivities to anti-tumor drugs, mitomycin C (MMC), aclarubicin hydrochloride (ACR), doxorubicin hydrochloride (ADR), cisplatin, and 5-fluorouracil (5FU), were examined using PK-1, -8, -9, -12, -14, and -16 cell lines derived from human pancreatic cancer. These cell lines showed different sensitivities to each of the above anti-tumor drugs. The concentrations required for 50% growth-inhibition (IC50) after 2 hours of exposure were 0.096 to 0.35 micrograms/ml for MMC, 0.0074 to 0.0076 micrograms/ml for ACR, 0.033 to 0.23 micrograms/ml for ADR, 0.35 to 1.9 micrograms/ml for cisplatin, and 21 to 42 micrograms/ml for 5FU, IC50 of each anti-tumor drug decreased significantly after 48 hours of exposure. The combination of any two out of MMC, ACR, and 5FU showed synergistic inhibition of the growth of PK-1 and PK-8 cell lines. These results show that MMC, ACR, ADR, cisplatin, and 5FU have sufficient anti-tumor effect against six human pancreatic cancer cell lines even at clinically achievable concentrations and exposure times, and chemotherapy for pancreatic cancers requires naturally effective drug delivery into cancer tissues.

References

Jun 15, 1978·The New England Journal of Medicine·S E SalmonT E Moon
Jul 29, 1977·Science·A W Hamburger, S E Salmon
Jul 1, 1978·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B Barlogie, B Drewinko
Jan 1, 1977·International Journal of Cancer. Journal International Du Cancer·A A YunisD J Russin
Feb 1, 1977·Journal of the National Cancer Institute·J FoghJ D Loveless
May 15, 1975·International Journal of Cancer. Journal International Du Cancer·M LieberG Todaro
Nov 1, 1986·The Tohoku Journal of Experimental Medicine·M KobariT Tachibana
Jan 1, 1985·Cancer Chemotherapy and Pharmacology·B K Chang, J A Gregory
May 15, 1980·International Journal of Cancer. Journal International Du Cancer·R T MorganS G Gordon

❮ Previous
Next ❯

Citations

Jan 1, 1994·Cancer Chemotherapy and Pharmacology·I B ShchepotinS R Evans
Dec 1, 1996·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·Y SawabeT Oka
Jun 26, 1999·Cardiovascular and Interventional Radiology·K ShibuyaM Hiraoka
Dec 10, 2009·In Vitro Cellular & Developmental Biology. Animal·Evan S GlazerSteven A Curley
Mar 1, 1993·Peptides·B BattistiniP Sirois
Apr 26, 2000·BJU International·J B Nelson, M A Carducci
May 7, 2014·Journal of Theoretical Biology·Leslie Braziel JonesArdith W El-Kareh
Apr 1, 1995·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·K AmikuraS Matsuno

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.