Growth inhibitory effect of green tea extract and (-)-epigallocatechin in Ehrlich ascites tumor cells involves a cellular thiol-dependent activation of mitogenic-activated protein kinases

Chemico-biological Interactions
D Opare KennedyIsao Matsui-Yuasa

Abstract

The effect of green tea extract (GTE) in Ehrlich ascites tumor cells (EATC) was studied with respect to changes in the intracellular kinase system involving mitogen-activated protein kinases (MAPKs) and cellular thiol. We have previously shown a reduction in viability of EATC and tyrosine phosphorylation of 42 and 45 kDa proteins by GTE and its polyphenolic component, Epigallocatechin (EGC) (D.O. Kennedy, S. Nishimura, T. Hasuma, Y. Yoshihisa, S. Otani, I. Matsui-Yuasa, Involvement of protein tyrosine phosphorylation in the effect of green tea polyphenols on Ehrlich ascites tumor cells in vitro, Chem. Biol. Interact. 110 (1998) 159-172). Furthermore, GTE and EGC significantly decreased both cellular non-protein and protein sulfhydryl levels in EATC, but replenishing thiol stores with N-acetylcysteine (NAC) caused a recovery in cell viability, and therefore SH groups were identified as a novel target of green tea cytotoxicity (D.O. Kennedy, M. Matsumoto, A. Kojima, I. Matsui-Yuasa, Cellular thiol status and cell death in the effect of green tea polyphenols in Ehrlich ascites tumor cells, Chem. Biol. Interact. 122 (1999) 59-71). In this study, we have observed the stimulation of three forms of MAPK, namely ERK1/2, JNK/SAPK and p3...Continue Reading

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Citations

Jan 19, 2008·Journal of Nutritional Science and Vitaminology·Saeda KametaniIsao Matsui-Yuasa
Jun 2, 2015·Pharmaceutical Biology·Indrajit KarmakarPallab Kanti Haldar
May 23, 2008·The Journal of Nutritional Biochemistry·Ana Belén Granado-SerranoSonia Ramos
Feb 1, 2006·Basic & Clinical Pharmacology & Toxicology·Fumie HisamuraIsao Matsui-Yuasa
Jan 25, 2003·Journal of Biochemistry and Molecular Biology·Ann M Park, Zigang Dong
Jul 22, 2015·Asian Pacific Journal of Tropical Medicine·Md Reyazul IslamShayla Islam Jenny
Apr 26, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S S AgrawalManeesha Pandey
Mar 15, 2017·MedChemComm·Entsar A SaadNada M ELmenawy
Jan 19, 2007·Journal of Medicinal Chemistry·Helena GradisarRoman Jerala
Jul 20, 2004·Chemical Research in Toxicology·Liuji ChenBaolu Zhao

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