Growth inhibitory effect of Krüppel-like factor 6 on human prostatic carcinoma and renal carcinoma cell lines

The Tohoku Journal of Experimental Medicine
Xian-Feng ChengToshio Hattori

Abstract

Kidney and prostate cancers are leading causes of death in the world, and accumulating evidence suggests that tumor suppressor gene, Krüppel-like factor 6 (KLF6), plays an important role in both the development and the progression of cancer. However, the effect of wild type KLF6 (wtKLF6) on the growth potential of renal carcinoma cells has not been examined. In the present study, we therefore introduced wtKLF6 gene into a prostatic carcinoma derived cell line, DU145, and a renal carcinoma derived cell line, OS-RC-2, and have established DU145-KLF6 and OS-RC-2-KLF6 cell lines, both of which stably over-express KLF6. Compared with vector-transfected cell lines (control cells), the wtKLF6-transfected cell lines showed the lower proliferation capacity (p < 0.01) and higher percentages of cells with apoptotic signals (p < 0.01). Moreover, the KLF6-overexpressed cell lines showed significant increases in the cell population at G0/G1 phase and significant decreases in the cell population at S and G2/M phases. There was no significant difference in the results of the cell cycle analysis between the two KLF6-overexpressed cell lines, DU145-KLF6 and OS-RC-2-KLF6. The cyclin-dependent kinase inhibitor p21 as a transcriptional target of th...Continue Reading

References

Jan 4, 2001·The International Journal of Biochemistry & Cell Biology·D T DangV W Yang
Jun 26, 2001·Journal of Cellular Physiology·A R BlackJ Azizkhan-Clifford
Jul 10, 2001·The Journal of Biological Chemistry·J J Bieker
Jul 27, 2001·Mechanisms of Development·F LaubS Friedman
Dec 12, 2001·BJU International·Z KirkaliM U Mungan
Jun 28, 2002·Cancer Cell·Dinesh SinghWilliam R Sellers
Mar 7, 2003·Genome Biology·Joanna KaczynskiRaul Urrutia
Mar 26, 2003·The American Journal of Pathology·Ceshi ChenJin-Tang Dong
May 13, 2003·International Journal of Cancer. Journal International Du Cancer·Yung-Ming Jeng, Hey-Chi Hsu
Aug 5, 2003·Genome Génome / Conseil National De Recherches Canada·E SchnabelJ Frugoli
Apr 7, 2004·The Journal of Clinical Investigation·Gennadi V GlinskyWilliam L Gerald
Oct 16, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sigal Kremer-TalScott L Friedman
Mar 29, 2005·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Shaoping WangFazu Qiu
Apr 13, 2005·Oncogene·Yong Gu ChoWon Sang Park
Jul 27, 2005·Oncogene·Astrid LièvrePierre Laurent-Puig
Aug 1, 2007·World Journal of Gastroenterology : WJG·Shinichi MukaiKazuaki Chayama

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Citations

Oct 21, 2010·Physiological Reviews·Beth B McConnell, Vincent W Yang
Oct 28, 2016·Apoptosis : an International Journal on Programmed Cell Death·Prahlad V RaningaKathryn F Tonissen

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