Growth-inhibitory effect of Scutellaria lindbergii in human cancer cell lines

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Zahra Tayarani-NajaranS A Emami

Abstract

Scutellaria lindbergii (Lamiaceae) is Iranian species of Scutellaria. Cytotoxic properties of total methanol extract of S. lindbergii and its fractions were investigated on different cancer cell lines including AGS, HeLa, MCF-7, and PC12. Meanwhile the role of apoptosis was explored in this toxicity. Malignant and non-malignant cells were cultured in DMEM medium and incubated with different concentrations of plant extracts. Cell viability was quantitated by MTT assay. Apoptotic cells were determined using PI staining of DNA fragmentation by flow cytometry (sub-G1 peak). S. lindbergii inhibited the growth of malignant cells in a dose-dependent manner. Among solvent fractions of S. lindbergii, the methylene chloride fraction was found to be more toxic compared to other fractions. S. lindbergii-induced a sub-G1 peak in flow cytometry histogram of treated cells compared to control indicating apoptotic cell death is involved in S. lindbergii-induced toxicity. In conclusion, S. lindbergii exerts cytotoxic effects in different cancer cell lines in which apoptosis plays an important role. Thus S. lindbergii could be considered as a potential chemotherapeutic agent in cancer treatment.

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Citations

Jun 25, 2013·Expert Opinion on Investigational Drugs·Su-Juan WangLu-Ping Qin
Jun 9, 2011·Drug and Chemical Toxicology·Hoda Atapour-MashhadSeyed Hadi Mousavi
Feb 13, 2016·Journal of Traditional and Complementary Medicine·Samira ShahrakiNafisa Sadat Tabasi
Apr 26, 2012·Scanning·Bingfang Wang, Xuewu Zhang
Nov 30, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Chin-Hung LiuTony Jer-Fu Lee
Apr 16, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Zahra Tayarani-NajaranSeyed Ahmad Emami
Dec 30, 2014·Environmental Toxicology and Pharmacology·Motahareh BoozariZahra Tayarani-Najaran
Jul 31, 2018·Nutritional Neuroscience·Elham HadipourMasoud Fereidoni
Mar 4, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Carmen Valadez-VegaAngel Morales-González
May 5, 2020·Current Drug Targets·Fatemeh Forouzanfar, Seyed Hadi Mousavi
Mar 20, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Samira EghbaliFerizZahra Tayarani-Najaran

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